2lfu: Difference between revisions
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==The structure of a N. meningitides protein targeted for vaccine development== | ==The structure of a N. meningitides protein targeted for vaccine development== | ||
<StructureSection load='2lfu' size='340' side='right'caption='[[2lfu | <StructureSection load='2lfu' size='340' side='right'caption='[[2lfu]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2lfu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LFU FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfu OCA], [https://pdbe.org/2lfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfu RCSB], [https://www.ebi.ac.uk/pdbsum/2lfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfu ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lfu OCA], [https://pdbe.org/2lfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lfu RCSB], [https://www.ebi.ac.uk/pdbsum/2lfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lfu ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/NHBA_NEIME NHBA_NEIME] A major human immunogenic protein detected in patients recovering from meningitidis, where it induces bactericidal antibodies (PubMed:30133484) (By similarity). Binds human cells, heparin and heparan sulfate proteoglycan in vitro via the Arg-rich motif. Heparin-binding to this protein protects bacteria against killing by bactericidal antibodies (serum killing). The bacteria binds a number of human extracellular sialyated and/or sulfated glycans via this protein, including chondroitin sulfate, heparin and ganglioside GT3. Binds DNA non-specifically (By similarity).[UniProtKB:Q7DD37]<ref>PMID:30133484</ref> May play a role in extracellular-DNA (eDNA) mediated biofilm formation. When NHBA is not processed by NalP there is an increase in biofilm formation (PubMed:23163582). Lack of processing may lead to an increase in positively charged, NHBA- and IgA-derived DNA-binding peptides on the cell surface, resulting in increased DNA-binding peptides and increased biofilm formation (Probable).<ref>PMID:23163582</ref> <ref>PMID:23163582</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chiara | [[Category: Neisseria meningitidis]] | ||
[[Category: Esposito | [[Category: De Chiara C]] | ||
[[Category: Kelly | [[Category: Esposito V]] | ||
[[Category: Musi | [[Category: Kelly G]] | ||
[[Category: Pastore | [[Category: Musi V]] | ||
[[Category: Pizza | [[Category: Pastore A]] | ||
[[Category: Veggi | [[Category: Pizza M]] | ||
[[Category: Veggi D]] | |||
