2m26: Difference between revisions
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==NMR structure of the C-terminal domain of the protein HCFC1 from Mus musculus== | |||
<StructureSection load='2m26' size='340' side='right'caption='[[2m26]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2m26]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M26 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
== | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m26 OCA], [https://pdbe.org/2m26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m26 RCSB], [https://www.ebi.ac.uk/pdbsum/2m26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m26 ProSAT]</span></td></tr> | ||
[[2m26]] is a 1 chain structure with sequence from [ | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/HCFC1_MOUSE HCFC1_MOUSE] Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.<ref>PMID:9334261</ref> <ref>PMID:9990006</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Dutta | [[Category: Dutta SK]] | ||
[[Category: Geralt | [[Category: Geralt M]] | ||
[[Category: Serrano P]] | |||
[[Category: Wuthrich K]] | |||
[[Category: Serrano | |||
[[Category: Wuthrich | |||
Latest revision as of 05:57, 15 May 2024
NMR structure of the C-terminal domain of the protein HCFC1 from Mus musculus
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