2m5v: Difference between revisions

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==Three-dimensional structure of human NLRP10/PYNOD pyrin domain==
==Three-dimensional structure of human NLRP10/PYNOD pyrin domain==
<StructureSection load='2m5v' size='340' side='right' caption='[[2m5v]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2m5v' size='340' side='right'caption='[[2m5v]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2m5v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2M5V FirstGlance]. <br>
<table><tr><td colspan='2'>[[2m5v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M5V FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NLRP10, NALP10, NOD8, PYNOD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5v OCA], [http://pdbe.org/2m5v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2m5v RCSB], [http://www.ebi.ac.uk/pdbsum/2m5v PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m5v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5v OCA], [https://pdbe.org/2m5v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m5v RCSB], [https://www.ebi.ac.uk/pdbsum/2m5v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m5v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NAL10_HUMAN NAL10_HUMAN]] Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.<ref>PMID:15096476</ref> <ref>PMID:20393137</ref> <ref>PMID:22672233</ref>
[https://www.uniprot.org/uniprot/NAL10_HUMAN NAL10_HUMAN] Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Plays a role in adaptive immunity through control of dendritic cell-mediated transport of antigen to the lymph nodes from peripheral sites. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection.<ref>PMID:15096476</ref> <ref>PMID:20393137</ref> <ref>PMID:22672233</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Chang, C F]]
[[Category: Large Structures]]
[[Category: Chang, C I]]
[[Category: Chang CF]]
[[Category: Su, M Y]]
[[Category: Chang CI]]
[[Category: Immune system]]
[[Category: Su MY]]
[[Category: Nlrp10]]
[[Category: Pynod]]
[[Category: Pyrin domain]]
Retrieved from "https://proteopedia.org/2m5v"