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==Solution Structure of human holo-PRL-3 in complex with vanadate==
==Solution Structure of human holo-PRL-3 in complex with vanadate==
<StructureSection load='2mbc' size='340' side='right' caption='[[2mbc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2mbc' size='340' side='right'caption='[[2mbc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2mbc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MBC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2mbc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBC FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1v3a|1v3a]], [[1r6h|1r6h]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTP4A3, PRL3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbc OCA], [https://pdbe.org/2mbc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbc RCSB], [https://www.ebi.ac.uk/pdbsum/2mbc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbc ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mbc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbc OCA], [http://pdbe.org/2mbc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2mbc RCSB], [http://www.ebi.ac.uk/pdbsum/2mbc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN]] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref>
[https://www.uniprot.org/uniprot/TP4A3_HUMAN TP4A3_HUMAN] Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.<ref>PMID:11355880</ref> <ref>PMID:12782572</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 2mbc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2mbc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]]
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Jeon, Y H]]
[[Category: Jeon YH]]
[[Category: Jeong, K]]
[[Category: Jeong K]]
[[Category: Jin, B]]
[[Category: Jin B]]
[[Category: Kang, D]]
[[Category: Kang D]]
[[Category: Kim, E]]
[[Category: Kim E]]
[[Category: Kim, J]]
[[Category: Kim J]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Lee, C]]
[[Category: Lee C]]
[[Category: Shin, S]]
[[Category: Shin S]]
[[Category: Holo-prl-3]]
[[Category: Hydrolase]]
[[Category: Vanadate]]
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