2mbj: Difference between revisions
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New page: '''Unreleased structure''' The entry 2mbj is ON HOLD Authors: Lim, K., Ng, V., Martin-Pintado, N., Heddi, B., Phan, A. Description: Structure of an antiparallel (2+2) G-quadruplex form... |
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==Structure of an antiparallel (2+2) G-quadruplex formed by human telomeric repeats in Na+ solution (with G22-to-BrG substitution)== | |||
<StructureSection load='2mbj' size='340' side='right'caption='[[2mbj]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mbj]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MBJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MBJ FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mbj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mbj OCA], [https://pdbe.org/2mbj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mbj RCSB], [https://www.ebi.ac.uk/pdbsum/2mbj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mbj ProSAT]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Single-stranded DNA overhangs at the ends of human telomeric repeats are capable of adopting four-stranded G-quadruplex structures, which could serve as potential anticancer targets. Out of the five reported intramolecular human telomeric G-quadruplex structures, four were formed in the presence of K+ ions and only one in the presence of Na+ ions, leading often to a perception that this structural polymorphism occurs exclusively in the presence of K+ but not Na+. Here we present the structure of a new antiparallel (2+2) G-quadruplex formed by a derivative of a 27-nt human telomeric sequence in Na+ solution, which comprises a novel core arrangement distinct from the known topologies. This structure complements the previously elucidated basket-type human telomeric G-quadruplex to serve as reference structures in Na+-containing environment. These structures, together with the coexistence of other conformations in Na+ solution as observed by nuclear magnetic resonance spectroscopy, establish the polymorphic nature of human telomeric repeats beyond the influence of K+ ions. | |||
Structure of the human telomere in Na+ solution: an antiparallel (2+2) G-quadruplex scaffold reveals additional diversity.,Lim KW, Ng VC, Martin-Pintado N, Heddi B, Phan AT Nucleic Acids Res. 2013 Sep 2. PMID:23999095<ref>PMID:23999095</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2mbj" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Heddi B]] | |||
[[Category: Lim KW]] | |||
[[Category: Martin-Pintado N]] | |||
[[Category: Ng VCM]] | |||
[[Category: Phan AT]] | |||
Latest revision as of 06:03, 15 May 2024
Structure of an antiparallel (2+2) G-quadruplex formed by human telomeric repeats in Na+ solution (with G22-to-BrG substitution)
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