2moq: Difference between revisions
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==Solution Structure and Molecular determinants of Hemoglobin Binding of the first NEAT Domain of IsdB in Staphylococcus aureus== | ==Solution Structure and Molecular determinants of Hemoglobin Binding of the first NEAT Domain of IsdB in Staphylococcus aureus== | ||
<StructureSection load='2moq' size='340' side='right' caption='[[2moq | <StructureSection load='2moq' size='340' side='right'caption='[[2moq]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2moq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOQ OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[2moq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MW2 Staphylococcus aureus subsp. aureus MW2]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MOQ FirstGlance]. <br> | ||
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<table> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2moq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2moq OCA], [https://pdbe.org/2moq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2moq RCSB], [https://www.ebi.ac.uk/pdbsum/2moq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2moq ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ISDB_STAAW ISDB_STAAW] Seems to function as the primary receptor for hemoglobin since its inactivation inhibits the ability of S.aureus to bind hemoglobin. Binds hemoglobin in a dose-dependent way. Required for S.aureus growth using hemoglobin as the sole iron source. Also required for virulence (By similarity). IsdA and/or IsdB promote resistance to hydrogen peroxide and killing by neutrophils.<ref>PMID:18097052</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2moq" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Copie | [[Category: Large Structures]] | ||
[[Category: Eilers | [[Category: Staphylococcus aureus subsp. aureus MW2]] | ||
[[Category: Fonner | [[Category: Copie V]] | ||
[[Category: Lei | [[Category: Eilers BJ]] | ||
[[Category: Lui | [[Category: Fonner BA]] | ||
[[Category: Moore | [[Category: Lei B]] | ||
[[Category: Stanisich | [[Category: Lui M]] | ||
[[Category: Sullivan-Springhetti | [[Category: Moore R]] | ||
[[Category: Tripet | [[Category: Stanisich J]] | ||
[[Category: Sullivan-Springhetti RK]] | |||
[[Category: Tripet BP]] | |||
