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==NMR STRUCTURE OF THE C TERMINAL DOMAIN OF CARDIAC TROPONIN C BOUND TO THE N TERMINAL DOMAIN OF CARDIAC TROPONIN I.==
==NMR STRUCTURE OF THE C TERMINAL DOMAIN OF CARDIAC TROPONIN C BOUND TO THE N TERMINAL DOMAIN OF CARDIAC TROPONIN I.==
<StructureSection load='1fi5' size='340' side='right'caption='[[1fi5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1fi5' size='340' side='right'caption='[[1fi5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1fi5]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ggs 1ggs]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1FI5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1fi5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ggs 1ggs]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1FI5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1fi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fi5 OCA], [http://pdbe.org/1fi5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1fi5 RCSB], [http://www.ebi.ac.uk/pdbsum/1fi5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1fi5 ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1fi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1fi5 OCA], [https://pdbe.org/1fi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1fi5 RCSB], [https://www.ebi.ac.uk/pdbsum/1fi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1fi5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TNNC1_CHICK TNNC1_CHICK]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.  
[https://www.uniprot.org/uniprot/TNNC1_CHICK TNNC1_CHICK] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
*[[Troponin|Troponin]]
*[[Troponin 3D structures|Troponin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abusamhadneh, E]]
[[Category: Abusamhadneh E]]
[[Category: Brito, R M]]
[[Category: Brito RM]]
[[Category: Finley, N]]
[[Category: Finley N]]
[[Category: Gaponenko, V]]
[[Category: Gaponenko V]]
[[Category: Gasmi-Seabrook, G M]]
[[Category: Gasmi-Seabrook GM]]
[[Category: Howarth, J W]]
[[Category: Howarth JW]]
[[Category: Rosevear, P R]]
[[Category: Rosevear PR]]
[[Category: Solaro, R J]]
[[Category: Solaro RJ]]
[[Category: Calcium binding protein]]
[[Category: Cardiac]]
[[Category: Contractile protein]]
[[Category: Muscle protein]]
[[Category: Troponin c-troponin i interaction]]
Retrieved from "https://proteopedia.org/1fi5"