1l2n: Difference between revisions

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{{Seed}}
[[Image:1l2n.png|left|200px]]


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==Smt3 Solution Structure==
The line below this paragraph, containing "STRUCTURE_1l2n", creates the "Structure Box" on the page.
<StructureSection load='1l2n' size='340' side='right'caption='[[1l2n]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1l2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1L2N FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1l2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2n OCA], [https://pdbe.org/1l2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1l2n RCSB], [https://www.ebi.ac.uk/pdbsum/1l2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1l2n ProSAT]</span></td></tr>
{{STRUCTURE_1l2n|  PDB=1l2n  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l2/1l2n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1l2n ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Smt3 belongs to a growing family of ubiquitin-related proteins involved in posttranslational protein modification. Independent studies demonstrate an essential function of Smt3 in the regulation of nucleocytoplasmic transport, and suggest a role in cell-cycle regulation. Here we report the high-resolution NMR structure of yeast Smt3 in the complex free form. Our comparison of the Smt3 NMR structure with the Smt3 crystal structure in complex with the C-Terminal Ulp1 protease domain revealed large structural differences in the binding surface, which is also involved in the Smt3-Ubc-9 interaction detected by NMR. The structural differences in the region indicate the important functions of conserved residues in less structurally defined sequences.


===Smt3 Solution Structure===
Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions.,Sheng W, Liao X Protein Sci. 2002 Jun;11(6):1482-91. PMID:12021447<ref>PMID:12021447</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1l2n" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_12021447}}, adds the Publication Abstract to the page
*[[SUMO 3D Structures|SUMO 3D Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 12021447 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_12021447}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1L2N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2N OCA].
 
==Reference==
Solution structure of a yeast ubiquitin-like protein Smt3: the role of structurally less defined sequences in protein-protein recognitions., Sheng W, Liao X, Protein Sci. 2002 Jun;11(6):1482-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12021447 12021447]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Single protein]]
[[Category: Liao X]]
[[Category: Liao, X.]]
[[Category: Sheng W]]
[[Category: Sheng, W.]]
[[Category: Nmr]]
[[Category: Smt3]]
[[Category: Structure]]
[[Category: Ubiquitin-like protein]]
 
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Retrieved from "https://proteopedia.org/1l2n"