1m31: Difference between revisions
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New page: left|200px<br /> <applet load="1m31" size="450" color="white" frame="true" align="right" spinBox="true" caption="1m31" /> '''Three-Dimensional Solution Structure of Apo... |
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== | ==Three-Dimensional Solution Structure of Apo-Mts1== | ||
Mts1 is a member of the S100 family of Ca2+-binding proteins and is | <StructureSection load='1m31' size='340' side='right'caption='[[1m31]]' scene=''> | ||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1m31]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M31 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M31 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m31 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m31 OCA], [https://pdbe.org/1m31 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m31 RCSB], [https://www.ebi.ac.uk/pdbsum/1m31 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m31 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S10A4_HUMAN S10A4_HUMAN] | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m3/1m31_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1m31 ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Mts1 is a member of the S100 family of Ca2+-binding proteins and is implicated in promoting tumor progression and metastasis. To better understand the structure-function relationships of this protein and to begin characterizing its Ca2+-dependent interaction with protein binding targets, the three-dimensional structure of mts1 was determined in the apo state by NMR spectroscopy. As with other S100 protein family members, mts1 is a symmetric homodimer held together by noncovalent interactions between two helices from each subunit (helices 1, 4, 1', and 4') to form an X-type four-helix bundle. Each subunit of mts1 has two EF-hand Ca2+-binding domains: a pseudo-EF-hand (or S100-hand) and a typical EF-hand that are brought into proximity by a small two-stranded antiparallel beta-sheet. The S100-hand is formed by helices 1 and 2, and is similar in conformation to other members of the S100 family. In the typical EF-hand, the position of helix 3 is similar to that of another member of the S100 protein family, calcyclin (S100A6), and less like that of other S100 family members for which three-dimensional structures are available in the calcium-free state (e.g., S100B and S100A1). The differences in the position of helix 3 in the apo state of these four S100 proteins are likely due to variations in the amino acid sequence in the C-terminus of helix 4 and in loop 2 (the hinge region) and could potentially be used to subclassify the S100 protein family. | |||
Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy.,Vallely KM, Rustandi RR, Ellis KC, Varlamova O, Bresnick AR, Weber DJ Biochemistry. 2002 Oct 22;41(42):12670-80. PMID:12379109<ref>PMID:12379109</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1m31" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[S100 proteins 3D structures|S100 proteins 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bresnick | [[Category: Bresnick AR]] | ||
[[Category: Ellis | [[Category: Ellis KC]] | ||
[[Category: Rustandi | [[Category: Rustandi RR]] | ||
[[Category: Vallely | [[Category: Vallely KM]] | ||
[[Category: Varlamova | [[Category: Varlamova O]] | ||
[[Category: Weber | [[Category: Weber DJ]] | ||
