2b3a: Difference between revisions
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==Solution structure of the Ras-binding domain of the Ral Guanosine Dissociation Stimulator== | |||
<StructureSection load='2b3a' size='340' side='right'caption='[[2b3a]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2b3a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B3A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B3A FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b3a OCA], [https://pdbe.org/2b3a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b3a RCSB], [https://www.ebi.ac.uk/pdbsum/2b3a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b3a ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/GNDS_HUMAN GNDS_HUMAN] Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
== | Check<jmol> | ||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b3/2b3a_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b3a ConSurf]. | |||
<div style="clear:both"></div> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Fuechsl | [[Category: Large Structures]] | ||
[[Category: Gronwald | [[Category: Fuechsl R]] | ||
[[Category: Herrmann | [[Category: Gronwald W]] | ||
[[Category: Kalbitzer | [[Category: Herrmann C]] | ||
[[Category: Maurer | [[Category: Kalbitzer HR]] | ||
[[Category: Wohlgemuth | [[Category: Maurer T]] | ||
[[Category: Wohlgemuth S]] | |||
Latest revision as of 09:23, 22 May 2024
Solution structure of the Ras-binding domain of the Ral Guanosine Dissociation Stimulator
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