2kdc: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
(9 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:2kdc.jpg|left|200px]]


<!--
==NMR Solution Structure of E. coli diacylglycerol kinase (DAGK) in DPC micelles==
The line below this paragraph, containing "STRUCTURE_2kdc", creates the "Structure Box" on the page.
<StructureSection load='2kdc' size='340' side='right'caption='[[2kdc]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kdc]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KDC FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kdc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kdc OCA], [https://pdbe.org/2kdc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kdc RCSB], [https://www.ebi.ac.uk/pdbsum/2kdc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kdc ProSAT]</span></td></tr>
{{STRUCTURE_2kdc|  PDB=2kdc  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDGL_ECOLI KDGL_ECOLI] Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kd/2kdc_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kdc ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Escherichia coli diacylglycerol kinase (DAGK) represents a family of integral membrane enzymes that is unrelated to all other phosphotransferases. We have determined the three-dimensional structure of the DAGK homotrimer with the use of solution nuclear magnetic resonance. The third transmembrane helix from each subunit is domain-swapped with the first and second transmembrane segments from an adjacent subunit. Each of DAGK's three active sites resembles a portico. The cornice of the portico appears to be the determinant of DAGK's lipid substrate specificity and overhangs the site of phosphoryl transfer near the water-membrane interface. Mutations to cysteine that caused severe misfolding were located in or near the active site, indicating a high degree of overlap between sites responsible for folding and for catalysis.


===NMR Solution Structure of E. coli diacylglycerol kinase (DAGK) in DPC micelles===
Solution nuclear magnetic resonance structure of membrane-integral diacylglycerol kinase.,Van Horn WD, Kim HJ, Ellis CD, Hadziselimovic A, Sulistijo ES, Karra MD, Tian C, Sonnichsen FD, Sanders CR Science. 2009 Jun 26;324(5935):1726-9. PMID:19556511<ref>PMID:19556511</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 2kdc" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19556511}}, adds the Publication Abstract to the page
*[[Diacylglycerol kinase 3D structures|Diacylglycerol kinase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19556511 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19556511}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Escherichia coli K-12]]
2KDC is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KDC OCA].
[[Category: Large Structures]]
 
[[Category: Ellis CD]]
==Reference==
[[Category: Hadziselimovic A]]
<ref group="xtra">PMID:19556511</ref><references group="xtra"/>
[[Category: Karra MD]]
[[Category: Diacylglycerol kinase]]
[[Category: Kim H]]
[[Category: Escherichia coli]]
[[Category: Sanders CR]]
[[Category: Ellis, C D.]]
[[Category: Sonnichsen FD]]
[[Category: Hadziselimovic, A.]]
[[Category: Sulistijo ES]]
[[Category: Horn, W D.Van.]]
[[Category: Tian C]]
[[Category: Karra, M D.]]
[[Category: Van Horn WD]]
[[Category: Kim, H.]]
[[Category: Sanders, C R.]]
[[Category: Sonnichsen, F D.]]
[[Category: Sulistijo, E S.]]
[[Category: Tian, C.]]
[[Category: Cell inner membrane]]
[[Category: Cell membrane]]
[[Category: Dagk]]
[[Category: Kinase]]
[[Category: Membrane]]
[[Category: Membrane protein]]
[[Category: Phospholipid biosynthesis]]
[[Category: Solution nmr]]
[[Category: Transferase]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul  8 09:30:02 2009''

Latest revision as of 09:37, 22 May 2024

NMR Solution Structure of E. coli diacylglycerol kinase (DAGK) in DPC micelles

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=2kdc&oldid=4158095"