2d8s: Difference between revisions

<StructureSection load='2d8s' size='340' side='right'caption='[[2d8s]]' scene=''>

== Structural highlights ==

<table><tr><td colspan='2'>[[2d8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8S FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8s OCA], [https://pdbe.org/2d8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8s RCSB], [https://www.ebi.ac.uk/pdbsum/2d8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8s ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8s TOPSAN]</span></td></tr>

[https://www.uniprot.org/uniprot/MARH8_HUMAN MARH8_HUMAN] E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:34285233, PubMed:35019698, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:19117940, PubMed:19566897). Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins (PubMed:32934085). Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation (PubMed:35019698). Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses (PubMed:34285233, PubMed:35019698). Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Blocks also ebola virus glycoprotein/GP incorporation via surface down-regulation (PubMed:32934085). Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation (PubMed:34285233). Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway (PubMed:28320822). Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination (PubMed:34183449). Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863).<ref>PMID:12582153</ref> <ref>PMID:14722266</ref> <ref>PMID:18389477</ref> <ref>PMID:19117940</ref> <ref>PMID:19566897</ref> <ref>PMID:28320822</ref> <ref>PMID:32934085</ref> <ref>PMID:34183449</ref> <ref>PMID:34285233</ref> <ref>PMID:35019698</ref> <ref>PMID:35503863</ref>  (Microbial infection) Mediates 'Lys-63'-linked polyubiquitination of hepatitis C virus/HCV protein NS2 which allows its binding to HGS, an ESCRT-0 complex component, and this interaction is essential for HCV envelopment.<ref>PMID:30759391</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

    <text>to colour the structure by Evolutionary Conservation</text>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2d8s ConSurf].

[[Category: Large Structures]]

[[Category: Inoue M]]

[[Category: Kigawa T]]

[[Category: Koshiba S]]

[[Category: Miyamoto K]]

[[Category: Tomizawa T]]

[[Category: Yokoyama S]]