2dun: Difference between revisions

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[[Image:2dun.png|left|200px]]


{{STRUCTURE_2dun|  PDB=2dun  |  SCENE=  }}
==Solution structure of BRCT domain of DNA polymerase mu==
 
<StructureSection load='2dun' size='340' side='right'caption='[[2dun]]' scene=''>
===Solution structure of BRCT domain of DNA polymerase mu===
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2dun]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DUN FirstGlance]. <br>
{{ABSTRACT_PUBMED_017915942}}
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dun OCA], [https://pdbe.org/2dun PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dun RCSB], [https://www.ebi.ac.uk/pdbsum/2dun PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dun ProSAT], [https://www.topsan.org/Proteins/RSGI/2dun TOPSAN]</span></td></tr>
==About this Structure==
</table>
[[2dun]] is a 1 chain structure of [[DNA polymerase]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DUN OCA].  
== Function ==
[https://www.uniprot.org/uniprot/DPOLM_HUMAN DPOLM_HUMAN] Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.<ref>PMID:12640116</ref> <ref>PMID:12888504</ref> <ref>PMID:17483519</ref> <ref>PMID:17915942</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/du/2dun_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dun ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[DNA polymerase|DNA polymerase]]
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017915942</ref><references group="xtra"/>
__TOC__
[[Category: DNA-directed DNA polymerase]]
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hayashi, F.]]
[[Category: Large Structures]]
[[Category: Nagashima, T.]]
[[Category: Hayashi F]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Nagashima T]]
[[Category: Yokoyama, S.]]
[[Category: Yokoyama S]]
[[Category: 3 layers a/b/a]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Non-homologous end jonting]]
[[Category: Nppsfa]]
[[Category: Parallel beta-sheet of 4 strand]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Somatic hypermutation]]
[[Category: Structural genomic]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2dun"