2e8s: Difference between revisions

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[[Image:2e8s.jpg|left|200px]]


{{Structure
==Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3==
|PDB= 2e8s |SIZE=350|CAPTION= <scene name='initialview01'>2e8s</scene>, resolution 2.50&Aring;
<StructureSection load='2e8s' size='340' side='right'caption='[[2e8s]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
<table><tr><td colspan='2'>[[2e8s]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2E8S FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphthine_synthase Diphthine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.98 2.1.1.98] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
|GENE=
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2e8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8s OCA], [https://pdbe.org/2e8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2e8s RCSB], [https://www.ebi.ac.uk/pdbsum/2e8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2e8s ProSAT], [https://www.topsan.org/Proteins/RSGI/2e8s TOPSAN]</span></td></tr>
|RELATEDENTRY=[[2e8q|2E8Q]], [[2e8r|2E8R]]
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2e8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2e8s OCA], [http://www.ebi.ac.uk/pdbsum/2e8s PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2e8s RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/DPHB_PYRHO DPHB_PYRHO] S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis.<ref>PMID:20873788</ref>
 
== Evolutionary Conservation ==
'''Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3'''
[[Image:Consurf_key_small.gif|200px|right]]
 
Check<jmol>
 
  <jmolCheckbox>
==About this Structure==
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/e8/2e8s_consurf.spt"</scriptWhenChecked>
2E8S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2E8S OCA].  
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Diphthine synthase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Pyrococcus horikoshii]]
  </jmolCheckbox>
[[Category: Single protein]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2e8s ConSurf].
[[Category: Asada, Y.]]
<div style="clear:both"></div>
[[Category: Kunishima, N.]]
== References ==
[[Category: Nakamoto, T.]]
<references/>
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
__TOC__
[[Category: Shimada, H.]]
</StructureSection>
[[Category: Taketa, M.]]
[[Category: Large Structures]]
[[Category: national project on protein structural and functional analyse]]
[[Category: Pyrococcus horikoshii OT3]]
[[Category: nppsfa]]
[[Category: Asada Y]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: Kunishima N]]
[[Category: rsgi]]
[[Category: Nakamoto T]]
[[Category: structural genomic]]
[[Category: Shimada H]]
[[Category: transferase]]
[[Category: Taketa M]]
 
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Retrieved from "https://proteopedia.org/2e8s"