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[[Image:2eob.png|left|200px]]


{{STRUCTURE_2eob| PDB=2eob | SCENE= }}
==Solution structure of the second SH2 domain from rat PLC gamma-2==
<StructureSection load='2eob' size='340' side='right'caption='[[2eob]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2eob]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eob FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eob OCA], [https://pdbe.org/2eob PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eob RCSB], [https://www.ebi.ac.uk/pdbsum/2eob PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eob ProSAT], [https://www.topsan.org/Proteins/RSGI/2eob TOPSAN]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PLCG2_RAT PLCG2_RAT] The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/eo/2eob_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2eob ConSurf].
<div style="clear:both"></div>


===Solution structure of the second SH2 domain from rat PLC gamma-2===
==See Also==
 
*[[Phospholipase C|Phospholipase C]]
 
__TOC__
==About this Structure==
</StructureSection>
[[2eob]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOB OCA].
[[Category: Large Structures]]
[[Category: Phosphoinositide phospholipase C]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Nagashima, T.]]
[[Category: Nagashima T]]
[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
[[Category: Sano R]]
[[Category: Sano, R.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: Hydrolase]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Phosphoinositide phospholipase c]]
[[Category: Phospholipase c-gamma-2]]
[[Category: Plc-gamma-2]]
[[Category: Plc-iv]]
[[Category: Riken structural genomics/proteomics initiative]]
[[Category: Rsgi]]
[[Category: Sh2]]
[[Category: Structural genomic]]
Retrieved from "https://proteopedia.org/2eob"