2f76: Difference between revisions

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{{Seed}}
[[Image:2f76.png|left|200px]]


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==Solution structure of the M-PMV wild type matrix protein (p10)==
The line below this paragraph, containing "STRUCTURE_2f76", creates the "Structure Box" on the page.
<StructureSection load='2f76' size='340' side='right'caption='[[2f76]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2f76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F76 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f76 OCA], [https://pdbe.org/2f76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f76 RCSB], [https://www.ebi.ac.uk/pdbsum/2f76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f76 ProSAT]</span></td></tr>
{{STRUCTURE_2f76|  PDB=2f76  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV] p10 is the matrix protein.  P14 is the nucleocapsid protein.  p27 is the capsid protein.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/2f76_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f76 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Despite extensive data demonstrating that immature retroviral particle assembly can take place either at the plasma membrane or at a distinct location within the cytoplasm, targeting of viral precursor proteins to either assembly site still remains poorly understood. Biochemical data presented here suggest that Tctex-1, a light chain of the molecular motor dynein, is involved in the intracellular targeting of Mason-Pfizer monkey virus (M-PMV) polyproteins to the cytoplasmic assembly site. Comparison of the three-dimensional structures of M-PMV wild-type matrix protein (wt MA) with a single amino acid mutant (R55F), which redirects assembly from a cytoplasmic site to the plasma membrane, revealed different mutual orientations of their C- and N-terminal domains. This conformational change buries a putative intracellular targeting motif located between both domains in the hydrophobic pocket of the MA molecule, thereby preventing the interaction with cellular transport mechanisms.


===Solution structure of the M-PMV wild type matrix protein (p10)===
D-retrovirus morphogenetic switch driven by the targeting signal accessibility to Tctex-1 of dynein.,Vlach J, Lipov J, Rumlova M, Veverka V, Lang J, Srb P, Knejzlik Z, Pichova I, Hunter E, Hrabal R, Ruml T Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10565-70. Epub 2008 Jul 22. PMID:18647839<ref>PMID:18647839</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2f76" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18647839 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_18647839}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2F76 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Simian_retrovirus_1 Simian retrovirus 1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F76 OCA].
 
==Reference==
<ref group="xtra">PMID:18647839</ref><references group="xtra"/>
[[Category: Simian retrovirus 1]]
[[Category: Simian retrovirus 1]]
[[Category: Hrabal, R.]]
[[Category: Hrabal R]]
[[Category: Hunter, E.]]
[[Category: Hunter E]]
[[Category: Lang, J.]]
[[Category: Lang J]]
[[Category: Lipov, J.]]
[[Category: Lipov J]]
[[Category: Ruml, T.]]
[[Category: Ruml T]]
[[Category: Rumlova, M.]]
[[Category: Rumlova M]]
[[Category: Srb, P.]]
[[Category: Srb P]]
[[Category: Veverka, V.]]
[[Category: Veverka V]]
[[Category: Vlach, J.]]
[[Category: Vlach J]]
[[Category: 4 alpha-helice]]
[[Category: Viral protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Aug 12 00:02:05 2010''

Latest revision as of 18:55, 29 May 2024

Solution structure of the M-PMV wild type matrix protein (p10)

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