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==Solution structure of the second SH3 domain of human Vinexin==
==Solution structure of the second SH3 domain of human Vinexin==
<StructureSection load='2yup' size='340' side='right'caption='[[2yup]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2yup' size='340' side='right'caption='[[2yup]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2yup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUP FirstGlance]. <br>
<table><tr><td colspan='2'>[[2yup]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YUP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YUP FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SORBS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yup OCA], [https://pdbe.org/2yup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yup RCSB], [https://www.ebi.ac.uk/pdbsum/2yup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yup ProSAT], [https://www.topsan.org/Proteins/RSGI/2yup TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yup FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yup OCA], [https://pdbe.org/2yup PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yup RCSB], [https://www.ebi.ac.uk/pdbsum/2yup PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yup ProSAT], [https://www.topsan.org/Proteins/RSGI/2yup TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/VINEX_HUMAN VINEX_HUMAN]] Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.  
[https://www.uniprot.org/uniprot/VINEX_HUMAN VINEX_HUMAN] Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Abe, H]]
[[Category: Abe H]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Koshiba, S]]
[[Category: Koshiba S]]
[[Category: Miyamoto, K]]
[[Category: Miyamoto K]]
[[Category: Structural genomic]]
[[Category: Saito K]]
[[Category: Saito, K]]
[[Category: Sasagawa A]]
[[Category: Sasagawa, A]]
[[Category: Tochio N]]
[[Category: Tochio, N]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Cell adhesion]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Scam-1]]
[[Category: Sh3-containing adapter molecule 1]]
[[Category: Sorbin and sh3 domain-containing protein 3]]
Retrieved from "https://proteopedia.org/2yup"