Complement factor: Difference between revisions

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== Function ==

'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement)<ref>PMID:15163532</ref>. '''Complement factor D''' (CFD) and '''Complement factor B''' (CFB) regulate a key step in the activation of the alternative complement pathway. CFD is a member of the chymotrypsin family of serine proteases. '''Complement factor I''' (CFI) is a serum protease that inhibits all complement pathways. '''Complement factor P''' (CFP) is a positive regulator of the alternative complement pathway<ref>PMID:28480349</ref>.

*'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response. CFH protects cells by preventing the activation of the complement system when it is not needed. CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement)<ref>PMID:15163532</ref>.

*'''Complement factor D''' (CFD) and '''Complement factor B''' (CFB) regulate a key step in the activation of the alternative complement pathway. CFD is a member of the chymotrypsin family of serine proteases.

*'''Complement factor I''' (CFI) is a serum protease that inhibits all complement pathways.

*'''Complement factor P''' (CFP) is a positive regulator of the alternative complement pathway<ref>PMID:28480349</ref>.

== Disease ==

Complement factor: Difference between revisions

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 == Function ==
-'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response.  CFH protects cells by preventing the activation of the complement system when it is not needed.  CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement)<ref>PMID:15163532</ref>. '''Complement factor D''' (CFD) and '''Complement factor B''' (CFB) regulate a key step in the activation of the alternative complement pathway.  CFD is a member of the chymotrypsin family of serine proteases. '''Complement factor I''' (CFI) is a serum protease that inhibits all complement pathways.  '''Complement factor P''' (CFP) is a positive regulator of the alternative complement pathway<ref>PMID:28480349</ref>.
+*'''Complement factor H''' (CFH) regulates the complement system which is part of the immune response.  CFH protects cells by preventing the activation of the complement system when it is not needed.  CFH contains 20 short consensus repeats (sushi domains, i.e., a 5 strand β-sandwich arrangement)<ref>PMID:15163532</ref>.
+*'''Complement factor D''' (CFD) and '''Complement factor B''' (CFB) regulate a key step in the activation of the alternative complement pathway.  CFD is a member of the chymotrypsin family of serine proteases.
+*'''Complement factor I''' (CFI) is a serum protease that inhibits all complement pathways.
+*'''Complement factor P''' (CFP) is a positive regulator of the alternative complement pathway<ref>PMID:28480349</ref>.
 == Disease ==