Cyclohydrolase: Difference between revisions
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== Function == | == Function == | ||
Cyclohydrolase is an enzyme which catalyzes the reversible cyclization or the ring opening of a purine ring. | '''Cyclohydrolase''' is an enzyme which catalyzes the reversible cyclization or the ring opening of a purine ring. | ||
• '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis<ref>PMID:7663943</ref> <br /> | • '''GTP cyclohydrolase I''' catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis<ref>PMID:7663943</ref> <br /> | ||
• '''GTP cyclohydrolase II''' catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.<ref>PMID:16115872</ref> <br /> | • '''GTP cyclohydrolase II''' catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism.<ref>PMID:16115872</ref> <br /> | ||
• '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis<ref>PMID:17407260</ref> <br /> | • '''IMP cyclohydrolase''' catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis<ref>PMID:17407260</ref> See also [[Bifunctional purine biosynthesis protein PURH]].<br /> | ||
• '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<ref>PMID:23013430</ref> <br /> | • '''Methenyltetrahydromethanopterin cyclohydrolase''' catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis<ref>PMID:23013430</ref> <br /> | ||
* | *'''Methylenetetrahydrofolate dehydrogenase/cyclohydrolase''' catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells.<ref>PMID:10828945</ref> | ||
*'''Phosphoribosyl AMP-cyclohydrolase''' catalyzes the third step of His biosynthesis.<ref>PMID:22741521</ref> | |||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
<scene name='59/595207/Cv/ | <scene name='59/595207/Cv/7'>GTP cyclohydrolase I</scene> from ''Escherichia coli'' ([[1n3r]]) is pentamer. <scene name='59/595207/Cv/8'>GCH I GTP binding pocket</scene> at the intersubunit interface.<ref>PMID:12559918</ref> <scene name='59/595207/Cv/9'>Surface representation of GCH I GTP binding pocket</scene>. | ||
==3D structures of cyclohydrolase== | ==3D structures of cyclohydrolase== | ||
Latest revision as of 10:26, 9 June 2024
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