Ficolin: Difference between revisions
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<StructureSection load='2j64' size='350' side='right' scene='' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '> | <StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '> | ||
== Function == | == Function == | ||
'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''. | '''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''. | ||
*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>. | |||
== Disease == | == Disease == | ||
Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>. | Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>. | ||
== Structural highlights == | |||
<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>. | |||
<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres. | |||
</StructureSection> | </StructureSection> | ||
== 3D Structures of Ficolin == | == 3D Structures of Ficolin == | ||
Latest revision as of 08:00, 23 June 2024
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3D Structures of Ficolin
Updated on 23-June-2024
