Importin: Difference between revisions

(4 intermediate revisions by the same user not shown)

Line 3:

== Function ==

'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the '''N'''uclear '''L'''ocalization '''S'''ignal (NLS). IPO has 2 subunits: α and β. '''IPO-α''' is an adaptor protein which binds the NLS<ref>PMID:9759490</ref>. IPOs can contain one or two NLS motifs. '''IPO-α''' contains several armadillo repeats with two NLS-binding sites and an IPO-β binding (IBB) site. '''IPO-β''' contains 19 HEAT (solenoid domain) repeats. Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported. See also [[Protein Transport Membrane Protein]].

'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the '''N'''uclear '''L'''ocalization '''S'''ignal (NLS). IPO has 2 subunits: α and β. '''IPO-α''' is an adaptor protein which binds the NLS<ref>PMID:9759490</ref>. IPOs can contain one or two NLS motifs.

*'''IPO-α''' contains several armadillo repeats with two NLS-binding sites and an IPO-β binding (IBB) site.

*'''IPO-β''' contains 19 HEAT (solenoid domain) repeats. Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.

*'''IPO-4''' binds histones H3 and H4 and histone chaperone ASF1 for nuclear import<ref>PMID:36103578</ref>.

*'''IPO-7''' drives the nuclear import of the regulator of mechanotransduction pathway YAP<ref>PMID:35246520</ref>.

*'''IPO-9''' binds histones H2A and H2B for nuclear import<ref>PMID:30855230</ref>.

*'''IPO-13''' has a role in oxidative stress-dependent nuclear export<ref>PMID:34625540</ref>.

See also [[Protein Transport Membrane Protein]].

== Disease ==

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 3: / Line 3: @@
 == Function ==
-'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the '''N'''uclear '''L'''ocalization '''S'''ignal (NLS).  IPO has 2 subunits: α and β.  '''IPO-α''' is an adaptor protein which binds the NLS<ref>PMID:9759490</ref>.  IPOs can contain one or two NLS motifs.  '''IPO-α''' contains several armadillo repeats with two NLS-binding sites and an IPO-β binding (IBB) site.  '''IPO-β''' contains 19 HEAT (solenoid domain) repeats.  Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.  See also [[Protein Transport Membrane Protein]].
+'''Importins''' (IPO) mediate the import of cellular proteins into the nucleus by binding to the '''N'''uclear '''L'''ocalization '''S'''ignal (NLS).  IPO has 2 subunits: α and β.  '''IPO-α''' is an adaptor protein which binds the NLS<ref>PMID:9759490</ref>.  IPOs can contain one or two NLS motifs.
+*'''IPO-α''' contains several armadillo repeats with two NLS-binding sites and an IPO-β binding (IBB) site.
+*'''IPO-β''' contains 19 HEAT (solenoid domain) repeats.  Many nuclear proteins contain Phe-Gly sequences which can bind to HEAT repeats and thus be transported.
+*'''IPO-4''' binds histones H3 and H4 and histone chaperone ASF1 for nuclear import<ref>PMID:36103578</ref>.
+*'''IPO-7'''  drives the nuclear import of the regulator of mechanotransduction pathway YAP<ref>PMID:35246520</ref>.
+*'''IPO-9''' binds histones H2A and H2B for nuclear import<ref>PMID:30855230</ref>.
+*'''IPO-13''' has a role in oxidative stress-dependent nuclear export<ref>PMID:34625540</ref>.
+See also [[Protein Transport Membrane Protein]].
 == Disease ==