Netrin receptor: Difference between revisions
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<StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | <StructureSection load='4urt' size='340' side='right' caption='Glycosylated human netrin receptor DCC fibronectin type V-VI domains (green) complex with neutrin-1 (grey), sulfate, Ca+2 and Cl-1 ions (PDB code [[4urt]])' scene=''> | ||
== Function == | == Function == | ||
'''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>. | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. | ||
*Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> . | |||
*'''UNC-5B receptor''' or '''UNC-5H2''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>. | |||
*'''UNC-5D receptor''' may mediate the effect of netrin-4 on cortical cell survival<ref>PMID:21216843</ref>. | |||
== Disease == | == Disease == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Netrin receptor DCC | *Netrin receptor DCC; domains – ectodomain 25-374; FN1 419-524; FN2 528-620; FN3 602-718; FN4 716-818; FN5 833-942; FN6 944-1044; P3 1390-1447. | ||
**[[2ed7]] – hDCC first fibronectin type III domain – human - NMR<BR /> | **[[2ed7]] – hDCC first fibronectin type III domain – human - NMR<BR /> | ||
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**[[2ede]] – hDCC sixth fibronectin type III domain - NMR<BR /> | **[[2ede]] – hDCC sixth fibronectin type III domain - NMR<BR /> | ||
**[[3au4]] – hDCC P3 motif + myosin-X <BR /> | **[[3au4]] – hDCC P3 motif + myosin-X <BR /> | ||
**[[6bz3]] – hDCC P3 motif + focal adhesion kinase FAT domain <BR /> | |||
**[[4urt]] – hDCC fibronectin type V-VI domains + neutrin-1 <BR /> | **[[4urt]] – hDCC fibronectin type V-VI domains + neutrin-1 <BR /> | ||
**[[5x83]] – hDCC fibronectin 4-6 domains <BR /> | |||
**[[4plo]] – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse<BR /> | **[[4plo]] – mDCC fourth fibronectin type IV domain + neutrin-1 - mouse<BR /> | ||
**[[3pzd]] – mDCC P3 motif + myosin-X <BR /> | **[[3pzd]] – mDCC P3 motif + myosin-X <BR /> | ||
**[[3laf]] – rDCC residues 39-421 - rat<BR /> | **[[3laf]] – rDCC residues 39-421 - rat<BR /> | ||
**[[5z5k]] – rDCC residues 39-421 + draxin peptide <BR /> | |||
*Netrin receptor UNC5 | |||
**[[8edc]] – `CeUNC5D Ig1+Ig2 domains 29-228 – ''Caenorhabditis elegans''<BR /> | |||
**[[8edi]] – `CeUNC5D Ig1+Ig2 domains + heparin<BR /> | |||
*Netrin receptor UNC5A | *Netrin receptor UNC5A | ||
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**[[4v2a]] – hUNC5A ectodomain <BR /> | **[[4v2a]] – hUNC5A ectodomain <BR /> | ||
*Netrin receptor UNC5B | *Netrin receptor UNC5B or UNC5H2 | ||
**[[3g5b]] – rUNC5B cytoplasmic domain (mutant)<BR /> | **[[6ool]] – mUNC5B ectodomain<BR /> | ||
**[[1wmg]] – mUNC5B death domain <BR /> | |||
**[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | |||
*Netrin receptor UNC5D | *Netrin receptor UNC5D | ||
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**[[4v2b]] – rUNC5D Ig1 domain <BR /> | **[[4v2b]] – rUNC5D Ig1 domain <BR /> | ||
**[[4v2c]] – rUNC5D Ig1 domain + FLRT2 LRR domain<BR /> | **[[4v2c]] – rUNC5D Ig1 domain + FLRT2 LRR domain<BR /> | ||
**[[7za1]], [[7za2]], [[7za3]] – rUNC5D residues 46-307 + glypican-3<BR /> | |||
**[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | **[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | |||
