Netrin receptor: Difference between revisions
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'''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. | '''Netrin receptors''' are cell surface proteins which bind netrins. Netrins direct cell and axon migration during development. | ||
*Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> . | *Netrin attraction is mediated through '''DCC (Deleted in Colorectal Cancer) receptors''' while netrin repulsion is mediated through the '''UNC-5 receptor'''<ref>PMID:18269208</ref>, <ref>PMID:11719202</ref> . | ||
*'''UNC-5B receptor''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>. | *'''UNC-5B receptor''' or '''UNC-5H2''' is a repulsive netrin recptor in endothelial cells controlling morphogenesis of the vascular system<ref>PMID:15510105</ref>. | ||
*'''UNC-5D receptor''' may mediate the effect of netrin-4 on cortical cell survival<ref>PMID:21216843</ref>. | *'''UNC-5D receptor''' may mediate the effect of netrin-4 on cortical cell survival<ref>PMID:21216843</ref>. | ||
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**[[4v2a]] – hUNC5A ectodomain <BR /> | **[[4v2a]] – hUNC5A ectodomain <BR /> | ||
*Netrin receptor UNC5B | *Netrin receptor UNC5B or UNC5H2 | ||
**[[6ool]] – mUNC5B ectodomain<BR /> | **[[6ool]] – mUNC5B ectodomain<BR /> | ||
**[[1wmg]] – mUNC5B death domain <BR /> | |||
**[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | **[[3g5b]] – rUNC5B cytoplasmic domain 541-945 (mutant)<BR /> | ||
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**[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | **[[5ftt]], [[5ftu]] – mUNC5D Ig1, Ig2, TSP1 domains + FLRT2 LRR domain + latrophilin 3<BR /> | ||
}} | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
