Sorting nexin: Difference between revisions

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<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>
<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''>
   
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association.  The PX domain contains a phospholipid-binding motif. 


==3D structures of sorting nexin==
__TOC__
== Function ==  
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>.  The PX domain contains a phospholipid-binding motif.


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
*'''SNX 1''' regulates trafficking in the endosome compartment<ref>PMID:11997453</ref>.<br />
*'''SNX 3''' regulates neurite formation<ref>PMID:19576982</ref>.<br />
*'''SNX 5''' regulates retrograde trafficking of transmembrane cargo receptors<ref>PMID:19553671</ref>.<br />
*'''SNX 7''' regulates the survival of cells in embryonic liver<ref>PMID:22213104</ref>.<br />
*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br />
*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br />
*'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br />
*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br />
*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br />
*'''SNX 16''' has a role in protein transport from early to late endosomes.<br />
*'''SNX 22''', '''SNX 24''', '''SNX 25''' and '''SNX 32''' may have a role in intracellular trafficking.<br />
*'''SNX 27''' modulates synaptic plasticity<ref>PMID:25071192</ref>.<br />
*'''SNX 33''' induces micronucleated phenotype and actin polymerization<ref>PMID:19487689</ref>.<br />


'''SNX-1'''
== Relevance ==
SNX 2 is a potential marker of hyperfunctioning thyroid disorders<ref>PMID:23531855</ref>.


[[2i4k]] – hSNX PX domain - NMR<br />
==3D structures of sorting nexin==
 
[[Sorting nexin 3D structures]]
'''SNX-3'''
 
[[1ocs]] – ySNX PX domain – yeast<br />
[[1ocu]] – ySNX PX domain + phosphatidylinositol-3-phosphate<br />
[[2yps]] – hSNX PX domain <br />
 
'''SNX-5'''
 
[[3hpb]], [[3hpc]] – rSNX PX domain – rat<br />
 
'''SNX-7'''
 
[[3iq2]] – hSNX PX domain <br />
 
'''SNX-9'''
 
[[2enm]] – SNX SH3 domain – mouse - NMR<br />
[[2rai]], [[2raj]], [[2rak]], [[3dyt]], [[3dyu]] – hSNX PX-BAR domain <br />
[[3lge]] – SNX residues 152-182 + aldolase – rabbit<br />
 
'''SNX-11'''
 
[[4ikb]], [[4ikd]] – hSNX PX domain <br />
 
'''SNX-12'''
 
[[2csk]] – hSNX PX domain <br />
 
'''SNX-14'''
 
[[4bgj]] – hSNX PX domain <br />
 
'''SNX-17'''
 
[[3fog]], [[3lui]] – hSNX PX domain <br />
[[4gxb]] – hSNX FERM domain + P-selectin NPXY motif<br />
 
'''SNX-22'''
 
[[2ett]] – hSNX PX domain - NMR<br />
 
'''SNX-24'''
 
[[4az9]] – hSNX PX domain <br />
 
'''SNX-27'''
 
[[3qdo]], [[3qe1]] – rSNX PDZ domain/GIRK3 C terminal  <br />
[[3qgl]] – rSNX PDZ domain + GIRK3 C terminal  <br />
[[4has]] – hSNX PX domain <br />


'''SNX-33'''
</StructureSection>


[[4akv]] – hSNX PH-BAR domain <br />
== References ==
<references/>
[[Category:Topic Page]]

Latest revision as of 10:06, 13 August 2024

Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry 3dyt)

Drag the structure with the mouse to rotate

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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