Sorting nexin: Difference between revisions
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<StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''> | <StructureSection load='3dyt' size='350' side='right' caption='Structure of human sorting nexin-9 PX domain complex with sulfate (PDB entry [[3dyt]])' scene=''> | ||
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== Function == | == Function == | ||
'''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>. The PX domain contains a phospholipid-binding motif. | '''Sorting nexins''' (SNX) are proteins which enhance membrane association via their lipid-binding PX domain or via protein-protein association<ref>PMID:25619244</ref>. The PX domain contains a phospholipid-binding motif. | ||
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*'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br /> | *'''SNX 9''' has a role in endocytosis<ref>PMID:12952949</ref>.<br /> | ||
*'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br /> | *'''SNX 10''' induces giant vacuoles in mammalian cells<ref>PMID:17012226</ref>.<br /> | ||
*'''SNX 11'''and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br /> | *'''SNX 11''' and '''SNX 17''' regulate lysosomal degradation of plasma membrane<ref>PMID:26818531</ref>.<br /> | ||
*'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br /> | *'''SNX 12''' regulates BACE1-mediated APP processing <ref>PMID:22709416</ref>.<br /> | ||
*'''SNX 14''' has a role in maintaining normal neuronal excitability.<br /> | *'''SNX 14''' has a role in maintaining normal neuronal excitability.<br /> | ||
