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| {{STRUCTURE_3lbx| PDB=3lbx | SIZE=300| SCENE= |right|CAPTION=Spectrin α (grey) and β chain (green) [[3lbx]] }}
| | <StructureSection load='3lbx' size='340' side='right' caption='Human spectrin α (grey) and β1 chain (green) [[3lbx]]' scene=''> |
| | == Function == |
| | [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. |
| | *'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>. |
| | *'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>. |
| | *'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses. |
| | *'''Spectrin R16''' is spectrin α first repeat domain<ref>PMID:10481916</ref>. |
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| [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.
| | == Disease == |
| | Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>. |
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| == 3D Structures of Spectrin == | | == 3D Structures of Spectrin == |
| | [[Spectrin 3D structures]] |
| | </StructureSection> |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Spectrin α1
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| **[[3lbx]] – hSPTA1+hSPTB1 – human<br />
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| **[[3i9q]], [[2rot]], [[2pqh]], [[2oaw]], [[2nuz]], [[1u06]] - cSPTA1 SH3 domain – chicken<br />
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| **[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]] - cSPTA1 SH3 domain (mutant)<br />
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| **[[2jma]], [[2jmc]] - cSPTA1 SH3 domain (mutant)+P41 peptide<br />
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| **[[2rmo]], [[1neg]], [[1m8m]] - cSPTA1 SH3 domain – NMR
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| * Spectrin α2
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| **[[3f31]] – hSPTA2 tetramerization domain<br />
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| **[[1qkw]] – cSPTA2 SH3 domain (mutant)<br />
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| **[[2fot]] - SPTA2+calmodulin – bovine<br />
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| **[[3fb2]] – hSPTA2 repeats 15-16<br />
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| **[[3thk]] - SPTA2 SH3 domain + polypeptide - rat
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| * Spectrin α
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| **[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
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| **[[2lj3]] - cSPTA SH3 domain – NMR<br />
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| **[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]] - cSPTA SH3 domain (mutant)<br />
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| **[[1u4q]] – cSPTA repeats 15-17 <br />
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| **[[1u5p]] - cSPTA repeats 15-16<br />
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| **[[1cun]] - cSPTA repeats 16-17<br />
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| **[[1aj3]] - cSPTA repeat 16 - NMR<br />
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| **[[1owa]] - hSPTA tetramerization domain – NMR<br />
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| **[[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] – cSPTA SH3 domain (mutant)<br />
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| **[[2kr3]], [[4f17]], [[4f16]] - cSPTA SH3 domain<br />
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| * Spectrin β1
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| **[[3bkt]], [[3kbu]] - hSPTB1+ankyrin<br />
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| **[[3f57]], [[3edu]] - hSPTB1 ankyrin binding domain<br />
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| **[[1s35]] – hSPTB1 repeats 8-9
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| * Spectrin β2
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| **[[3edv]] – hSPTB2 repeats 14-16
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| * Spectrin β3
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| **[[1wyq]] – hSPTB3 CH domain – NMR<br />
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| **[[1wjm]] – hSPTB3 – NMR
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| * Spectrin β
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| **[[1bkr]], [[1aa2]] – hSPTB CH domain<br />
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| **[[1mph]] – SPTB Pleckstrin Homology domain – NMR<br />
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| **[[1dro]] - mSPTB PH domain – NMR – mouse<br />
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| **[[1btn]] – mSPTB+inositol phosphate<br />
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| **[[2spc]] – SPT fragment - ''Drosophila melanogaster''
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
