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| == Function == | | == Function == |
| [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. | | [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. |
| | *'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>. |
| | *'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>. |
| | *'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses. |
| | *'''Spectrin R16''' is spectrin α first repeat domain<ref>PMID:10481916</ref>. |
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| == Disease == | | == Disease == |
| Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>. | | Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>. |
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| | == 3D Structures of Spectrin == |
| | [[Spectrin 3D structures]] |
| </StructureSection> | | </StructureSection> |
| == 3D Structures of Spectrin ==
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| {{#tree:id=OrganizedByTopic|openlevels=0|
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| * Spectrin α1; Domains – N-terminal tetramerization 1-156; SH3 969-1025; C-terminal tetramerization 1902-2084
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| **[[3lbx]] – hSPT a chain N-terminal tetramerization domain +hSPT b chain C-terminal tetramerization domain – human<br />
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| **[[2rot]], [[2oaw]], [[2nuz]], [[1u06]] - cSPT a chain SH3 domain – chicken<br />
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| **[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]], [[3i9q]] - cSPT a chain SH3 domain (mutant)<br />
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| **[[2rmo]], [[1neg]], [[1m8m]] - cSPT a chain SH3 domain – NMR<br />
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| **[[2jma]], [[2jmc]] - cSPT a chain SH3 domain (mutant)+P41 peptide<br />
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| * Spectrin α2
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| **[[3f31]] – hSPT a2 chain N-terminal tetramerization domain<br />
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| **[[3fb2]] – hSPT a2 chain repeats 15-16 1337-1544<br />
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| **[[5fw9]], [[5fwb]], [[5fwc]], [[5ihi]], [[5ihk]], [[5ihn]] – hSPT a2 chain SH3 domain (mutant)<br />
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| **[[2fot]] - SPT a2 chain calmodulin-binding domain 1172-1211 +calmodulin – bovine<br />
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| **[[3thk]] - SPT a2 chain SH3 domain + polypeptide - rat
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| **[[1qkw]] – cSPT a2 chain SH3 domain (mutant)<br />
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| * Spectrin α
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| **[[1owa]] - hSPT a chain N-terminal tetramerization domain – NMR<br />
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| **[[5j4o]] - hSPT a chain repeats 16-17 1599-1826<br />
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| **[[2kr3]], [[4f17]], [[4f16]] - cSPT a chain SH3 domain<br />
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| **[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]], [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] - cSPT a chain SH3 domain (mutant)<br />
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| **[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPT a chain SH3 domain (mutant) – NMR<br />
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| **[[2lj3]] - cSPT a chain SH3 domain – NMR<br />
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| **[[1u4q]] – cSPT a chain repeats 15-17 1662-1982<br />
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| **[[1u5p]] - cSPT a chain repeats 15-16 1662-1876<br />
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| **[[1cun]] - cSPT a chain repeats 16-17 (mutant) 1771-1982<br />
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| **[[1aj3]] - cSPT a chain repeat 16 1772-1869 - NMR<br />
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| * Spectrin β1
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| **[[3kbt]], [[3kbu]] - hSPT β1 chain repeats 13-15 1583-1906 +ankyrin<br />
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| **[[3f57]], [[3edu]] - hSPT β1 chain repeats 14-15 1686-1906<br />
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| **[[1s35]] – hSPT β1 chain repeats 8-9 1063-1275 (mutant)
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| * Spectrin β2
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| **[[3edv]] – hSPT β2 chain repeats 14-16 1697-2015
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| * Spectrin β3
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| **[[1wyq]] – hSPT β3 chain 2nd CH domain – NMR<br />
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| **[[1wjm]] – hSPT β3 chain PH domain 2199-2328 – NMR<br />
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| **[[6anu]] - hSPT β3 chain actin binding domain 1-284 + actin - Cryo EM<br />
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| * Spectrin β
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| **[[1bkr]], [[1aa2]] – hSPT β chain 2nd CH domain 178-291<br />
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| **[[1dro]], [[1mph]] - mSPT β chain PH domain 2199-2304 – NMR – mouse<br />
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| **[[1btn]] – mSPT β chain PH domain +inositol phosphate<br />
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| **[[2spc]] – SPT fragment 1391-1497 - ''Drosophila melanogaster''
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| * Spectrin R16
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| **[[5m6s]] – SPT - ''Escherichia coli''<br />
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |
