Transducin: Difference between revisions

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__TOC__

== Function ==

'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.

'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: '''α''' and '''βγ'''<ref>PMID:2534964</ref>. TDN is involved in phototransduction. The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II. The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm. Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.

== Disease ==

Transducin: Difference between revisions

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 <StructureSection load='' size='350' side='right' caption='Structure of rat transducin α (deepskyblue), β (green) and γ (gold) subunits complex with GDP (PDB code [[1gp2]]).' scene='59/590984/Cv/1' pspeed='8'>
+__TOC__
 == Function ==
-'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: α and βγ<ref>PMID:2534964</ref>. TDN is involved in phototransduction.  The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II.  The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm.  Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.
+'''Transducin''' (TDN) or '''Heterotrimeric G protein''' or '''Guanine nucleotide-binding protein G''' is a <scene name='59/590984/Cv/5'>heterotrimeric G protein containing 3 chains: α, β and γ</scene> which are organized in two subunits: '''α''' and '''βγ'''<ref>PMID:2534964</ref>. TDN is involved in phototransduction.  The absorption of a photon by retinal causes a change in the conformation of rhodopsin into metarhodopsin II.  The latter causes activation of TDN. Upon TDN activation the <scene name='59/590984/Cv/6'>GDP bound to its α subunit</scene> is exchanged for the GTP from the cytoplasm.  Deactivation of TDN occurs when the GTP bound to the α subunit is hydrolyzed to GDP. Phosducin binds to the βγ subunit of TDN preventing its re-association with the α subunit.
 == Disease ==