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==NMR SOLUTION STRUCTURE OF SCORPION VENOM TOXIN Ts11 (TsPep1) FROM Tityus serrulatus==
==NMR SOLUTION STRUCTURE OF SCORPION VENOM TOXIN Ts11 (TsPep1) FROM Tityus serrulatus==
<StructureSection load='2msf' size='340' side='right' caption='[[2msf]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='2msf' size='340' side='right'caption='[[2msf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2msf]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MSF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2msf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tityus_serrulatus Tityus serrulatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MSF FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2msf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2msf OCA], [http://pdbe.org/2msf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2msf RCSB], [http://www.ebi.ac.uk/pdbsum/2msf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2msf ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2msf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2msf OCA], [https://pdbe.org/2msf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2msf RCSB], [https://www.ebi.ac.uk/pdbsum/2msf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2msf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SCKP1_TITSE SCKP1_TITSE]] Not toxic to mouse.  
[https://www.uniprot.org/uniprot/KEX11_TITSE KEX11_TITSE] Potassium channel blocker. At 3 uM, this toxin blocks voltage-independently voltage-gated potassium channels rKv1.2/KCNA2 (25%), hKv1.3/KCNA3 (27%), rKv4.2/KCND2 (25%), Kv10.1/KCNH1/EAG1 (15%), Kv11/hERG (12%), and Shaker-IR (10%). On hKv1.3/KCNA3, the IC(50) is 17.1 +-3.3 uM.<ref>PMID:27706049</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arantes, E C]]
[[Category: Large Structures]]
[[Category: Cassoli, J S]]
[[Category: Tityus serrulatus]]
[[Category: Cremonez, C M]]
[[Category: Arantes EC]]
[[Category: Dutra, A A.A]]
[[Category: Cassoli JS]]
[[Category: Herdewijn, P]]
[[Category: Cremonez CM]]
[[Category: Lescrinier, E]]
[[Category: De Lima MH]]
[[Category: Lima, M H.De]]
[[Category: Dutra AAA]]
[[Category: Maiti, M]]
[[Category: Herdewijn P]]
[[Category: Peigneur, S]]
[[Category: Lescrinier E]]
[[Category: Pimenta, A M.C]]
[[Category: Maiti M]]
[[Category: Tytgat, J]]
[[Category: Peigneur S]]
[[Category: Waelkens, E]]
[[Category: Pimenta AMC]]
[[Category: Toxin]]
[[Category: Tytgat J]]
[[Category: Waelkens E]]
Retrieved from "https://proteopedia.org/2msf"