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==Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody==
==Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody==
<StructureSection load='3o2d' size='340' side='right' caption='[[3o2d]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='3o2d' size='340' side='right'caption='[[3o2d]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3o2d]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O2D FirstGlance]. <br>
<table><tr><td colspan='2'>[[3o2d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O2D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O2D FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CD4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2d OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3o2d RCSB], [http://www.ebi.ac.uk/pdbsum/3o2d PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o2d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o2d OCA], [https://pdbe.org/3o2d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o2d RCSB], [https://www.ebi.ac.uk/pdbsum/3o2d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o2d ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN]] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.  
[https://www.uniprot.org/uniprot/CD4_HUMAN CD4_HUMAN] Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3o2d" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[CD4|CD4]]
*[[CD4 3D structures|CD4 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Chen, B]]
[[Category: Chen B]]
[[Category: Freeman, M M]]
[[Category: Freeman MM]]
[[Category: Ho, D D]]
[[Category: Ho DD]]
[[Category: Hong, X]]
[[Category: Hong X]]
[[Category: Rits-Volloch, S]]
[[Category: Rits-Volloch S]]
[[Category: Seaman, M S]]
[[Category: Seaman MS]]
[[Category: Hiv-1 primary receptor]]
[[Category: Immune system]]
[[Category: Immunoglobulin fold]]
[[Category: Membrane]]
[[Category: Monoclonal antibody]]
[[Category: T cell coreceptor]]

Latest revision as of 08:05, 9 October 2024

Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody

3o2d, resolution 2.19Å

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