1spp: Difference between revisions

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{{Seed}}
[[Image:1spp.png|left|200px]]


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==THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN==
The line below this paragraph, containing "STRUCTURE_1spp", creates the "Structure Box" on the page.
<StructureSection load='1spp' size='340' side='right'caption='[[1spp]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1spp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SPP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1spp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1spp OCA], [https://pdbe.org/1spp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1spp RCSB], [https://www.ebi.ac.uk/pdbsum/1spp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1spp ProSAT]</span></td></tr>
{{STRUCTURE_1spp|  PDB=1spp  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/PSP1_PIG PSP1_PIG] Not yet identified, major porcine seminal plasma protein. Can bind soybean trypsin inhibitor after deglycosylation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sp/1spp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1spp ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Spermadhesins, 12,000-14,000 M(r) mammalian proteins, include lectins involved in sperm-egg binding and display a single CUB domain architecture. We report the crystal structures of porcine seminal plasma PSP-I/PSP-II, a heterodimer of two glycosylated spermadhesins, and bovine aSFP at 2.4 A and 1.9 A resolution respectively.


===THE CRYSTAL STRUCTURES OF TWO MEMBERS OF THE SPERMADHESIN FAMILY REVEAL THE FOLDING OF THE CUB DOMAIN===
The crystal structures of two spermadhesins reveal the CUB domain fold.,Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:9334740<ref>PMID:9334740</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_9334740}}, adds the Publication Abstract to the page
<div class="pdbe-citations 1spp" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 9334740 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_9334740}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
1SPP is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SPP OCA].
 
==Reference==
The crystal structures of two spermadhesins reveal the CUB domain fold., Romero A, Romao MJ, Varela PF, Kolln I, Dias JM, Carvalho AL, Sanz L, Topfer-Petersen E, Calvete JJ, Nat Struct Biol. 1997 Oct;4(10):783-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9334740 9334740]
[[Category: Protein complex]]
[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
[[Category: Calvete, J J.]]
[[Category: Calvete JJ]]
[[Category: Carvalho, A L.]]
[[Category: Carvalho AL]]
[[Category: Dias, J M.]]
[[Category: Dias JM]]
[[Category: Kolln, I.]]
[[Category: Kolln I]]
[[Category: Romao, M J.]]
[[Category: Romao MJ]]
[[Category: Romero, A.]]
[[Category: Romero A]]
[[Category: Sanz, L.]]
[[Category: Sanz L]]
[[Category: Topfer-Petersen, E.]]
[[Category: Topfer-Petersen E]]
[[Category: Varela, P F.]]
[[Category: Varela PF]]
[[Category: Cub domain architecture]]
[[Category: Seminal plasma protein]]
[[Category: Spermadhesin]]
 
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Retrieved from "https://proteopedia.org/1spp"