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==Crystal structure of rat coronavirus strain New-Jersey Hemagglutinin-Esterase in complex with 4N-acetyl sialic acid==
==Crystal structure of rat coronavirus strain New-Jersey Hemagglutinin-Esterase in complex with 4N-acetyl sialic acid==
<StructureSection load='5jil' size='340' side='right' caption='[[5jil]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='5jil' size='340' side='right'caption='[[5jil]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5jil]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JIL FirstGlance]. <br>
<table><tr><td colspan='2'>[[5jil]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rat_coronavirus Rat coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JIL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6KL:METHYL+4,5-BIS(ACETYLAMINO)-3,4,5-TRIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSIDONIC+ACID'>6KL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sialate_O-acetylesterase Sialate O-acetylesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.53 3.1.1.53] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6KL:METHYL+4,5-BIS(ACETYLAMINO)-3,4,5-TRIDEOXY-D-GLYCERO-ALPHA-D-GALACTO-NON-2-ULOPYRANOSIDONIC+ACID'>6KL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jil OCA], [http://pdbe.org/5jil PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jil RCSB], [http://www.ebi.ac.uk/pdbsum/5jil PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jil OCA], [https://pdbe.org/5jil PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jil RCSB], [https://www.ebi.ac.uk/pdbsum/5jil PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jil ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q3HS77_9BETC Q3HS77_9BETC]] May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture.[RuleBase:RU361278]  
[https://www.uniprot.org/uniprot/Q3HS77_9BETC Q3HS77_9BETC] May serve as a secondary viral attachment protein for initiating infection, the spike protein being the major one. Structural protein that makes short spikes at the surface of the virus. Contains receptor binding and receptor-destroying activities. Seems to be a 'luxury' protein that is not absolutely necessary for virus infection in culture.[RuleBase:RU361278]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5jil" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5jil" style="background-color:#fffaf0;"></div>
==See Also==
*[[Hemagglutinin-esterase 3D structures|Hemagglutinin-esterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Sialate O-acetylesterase]]
[[Category: Large Structures]]
[[Category: Bakkers, M J.G]]
[[Category: Rat coronavirus]]
[[Category: Feitsma, L J]]
[[Category: Bakkers MJG]]
[[Category: Groot, R J.de]]
[[Category: Feitsma LJ]]
[[Category: Huizinga, E G]]
[[Category: Huizinga EG]]
[[Category: Coronavirus]]
[[Category: De Groot RJ]]
[[Category: Esterase]]
[[Category: Hemagglutin]]
[[Category: Hepatitis virus]]
[[Category: Sialic acid]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/5jil"