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==INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH AZD5991==
==INDUCED MYELOID LEUKEMIA CELL DIFFERENTIATION PROTEIN FABCOMPLEX IN COMPLEX WITH AZD5991==
<StructureSection load='6fs0' size='340' side='right' caption='[[6fs0]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
<StructureSection load='6fs0' size='340' side='right'caption='[[6fs0]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fs0]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FS0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FS0 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fs0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FS0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FS0 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4W:AZD5991'>E4W</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fs0 OCA], [https://pdbe.org/6fs0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fs0 RCSB], [https://www.ebi.ac.uk/pdbsum/6fs0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fs0 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5mes|5mes]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fs0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fs0 OCA], [http://pdbe.org/6fs0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fs0 RCSB], [http://www.ebi.ac.uk/pdbsum/6fs0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fs0 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/MCL1_HUMAN MCL1_HUMAN]] Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.<ref>PMID:10766760</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6fs0" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6fs0" style="background-color:#fffaf0;"></div>
==See Also==
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Hargreaves, D]]
[[Category: Homo sapiens]]
[[Category: Apoptosis]]
[[Category: Large Structures]]
[[Category: Mcl1-fab4460 55]]
[[Category: Hargreaves D]]
Retrieved from "https://proteopedia.org/6fs0"