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==SOLUTION STRUCTURE OF OMEGA-CONOTOXIN MVIIC, A HIGH AFFINITY OF P-TYPE CALCIUM CHANNELS, USING 1H NMR SPECTROSCOPY AND COMPLETE RELAXATION MATRIX ANALYSIS==
==SOLUTION STRUCTURE OF OMEGA-CONOTOXIN MVIIC, A HIGH AFFINITY OF P-TYPE CALCIUM CHANNELS, USING 1H NMR SPECTROSCOPY AND COMPLETE RELAXATION MATRIX ANALYSIS==
<StructureSection load='1omn' size='340' side='right' caption='[[1omn]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
<StructureSection load='1omn' size='340' side='right'caption='[[1omn]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1omn]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OMN FirstGlance]. <br>
<table><tr><td colspan='2'>[[1omn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_magus Conus magus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OMN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OMN FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1omn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omn OCA], [http://pdbe.org/1omn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1omn RCSB], [http://www.ebi.ac.uk/pdbsum/1omn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1omn ProSAT]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1omn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1omn OCA], [https://pdbe.org/1omn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1omn RCSB], [https://www.ebi.ac.uk/pdbsum/1omn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1omn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CO7C_CONMA CO7C_CONMA]] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A).<ref>PMID:1352986</ref>
[https://www.uniprot.org/uniprot/O17C_CONMA O17C_CONMA] Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC(50)=0.60 nM) (PubMed:10938268, PubMed:1352986). Shows also an inhibition on Cav2.2/CACNA1A channels (IC(50)=7.0 nM) (PubMed:10938268).<ref>PMID:10938268</ref> <ref>PMID:1352986</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Conus magus]]
[[Category: Conus magus]]
[[Category: Basus, V J]]
[[Category: Large Structures]]
[[Category: Farr-Jones, S]]
[[Category: Basus VJ]]
[[Category: Conotoxin]]
[[Category: Farr-Jones S]]
[[Category: Conus venom]]
[[Category: Neurotoxin]]
[[Category: P-type calcium channel blocker]]
[[Category: Presynaptic neurotoxin]]
Retrieved from "https://proteopedia.org/1omn"