2br9: Difference between revisions

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==14-3-3 Protein Epsilon (Human) Complexed to Peptide==
==14-3-3 Protein Epsilon (Human) Complexed to Peptide==
<StructureSection load='2br9' size='340' side='right' caption='[[2br9]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='2br9' size='340' side='right'caption='[[2br9]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2br9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BR9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2br9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BR9 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2br9 OCA], [http://pdbe.org/2br9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2br9 RCSB], [http://www.ebi.ac.uk/pdbsum/2br9 PDBsum]</span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2br9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2br9 OCA], [https://pdbe.org/2br9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2br9 RCSB], [https://www.ebi.ac.uk/pdbsum/2br9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2br9 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/1433E_HUMAN 1433E_HUMAN] Distal 17p13.3 microdeletion syndrome;17p13.3 microduplication syndrome;Miller-Dieker syndrome.
== Function ==
[https://www.uniprot.org/uniprot/1433E_HUMAN 1433E_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/2br9_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/2br9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[14-3-3 protein|14-3-3 protein]]
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C]]
[[Category: Large Structures]]
[[Category: Doyle, D A]]
[[Category: Arrowsmith C]]
[[Category: Edwards, A]]
[[Category: Doyle DA]]
[[Category: Elkins, J M]]
[[Category: Edwards A]]
[[Category: Fedorov, O]]
[[Category: Elkins JM]]
[[Category: Soundararajan, M]]
[[Category: Fedorov O]]
[[Category: Sundstrom, M]]
[[Category: Soundararajan M]]
[[Category: Yang, X]]
[[Category: Sundstrom M]]
[[Category: 14-3-3]]
[[Category: Yang X]]
[[Category: Cell regulator protein]]
[[Category: Phosphoserine]]
[[Category: Sgc]]
[[Category: Structural genomic]]
[[Category: Ywhae]]
Retrieved from "https://proteopedia.org/2br9"