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<StructureSection load='7d5a' size='340' side='right'caption='[[7d5a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='7d5a' size='340' side='right'caption='[[7d5a]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7d5a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5A FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7D5A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7D5A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GX6:N-[3-[(9S)-7-azanyl-2,2-bis(fluoranyl)-9-prop-1-ynyl-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4-fluoranyl-phenyl]-5-cyano-pyridine-2-carboxamide'>GX6</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE1, BACE, KIAA1149 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GX6:N-[3-[(9S)-7-azanyl-2,2-bis(fluoranyl)-9-prop-1-ynyl-6-oxa-8-azaspiro[3.5]non-7-en-9-yl]-4-fluoranyl-phenyl]-5-cyano-pyridine-2-carboxamide'>GX6</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5a OCA], [https://pdbe.org/7d5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5a RCSB], [https://www.ebi.ac.uk/pdbsum/7d5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7d5a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7d5a OCA], [https://pdbe.org/7d5a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7d5a RCSB], [https://www.ebi.ac.uk/pdbsum/7d5a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7d5a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7d5a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7d5a" style="background-color:#fffaf0;"></div>
==See Also==
*[[Beta secretase 3D structures|Beta secretase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Memapsin 2]]
[[Category: Ando S]]
[[Category: Ando, S]]
[[Category: Asada N]]
[[Category: Asada, N]]
[[Category: Fuchino K]]
[[Category: Fuchino, K]]
[[Category: Fujimoto K]]
[[Category: Fujimoto, K]]
[[Category: Gijsen HJM]]
[[Category: Gijsen, H J.M]]
[[Category: Ito H]]
[[Category: Ito, H]]
[[Category: Kanegawa N]]
[[Category: Kanegawa, N]]
[[Category: Kusakabe KI]]
[[Category: Kusakabe, K I]]
[[Category: Matsuoka E]]
[[Category: Matsuoka, E]]
[[Category: Moechars D]]
[[Category: Moechars, D]]
[[Category: Rombouts FJR]]
[[Category: Rombouts, F J.R]]
[[Category: Suzuki S]]
[[Category: Suzuki, S]]
[[Category: Tadano G]]
[[Category: Tadano, G]]
[[Category: Tonomura Y]]
[[Category: Tonomura, Y]]
[[Category: Yamamoto S]]
[[Category: Yamamoto, S]]
[[Category: Yamamoto T]]
[[Category: Yamamoto, T]]
[[Category: Yoshida S]]
[[Category: Yoshida, S]]
[[Category: Bace1]]
[[Category: Hydrolase]]
Retrieved from "https://proteopedia.org/7d5a"