7oim: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 7oim is ~~ON HOLD~~

==Mouse RNF213, with mixed nucleotides bound==

== Structural highlights ==

<table><tr><td colspan='2'>[[7oim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OIM OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7OIM FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7oim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oim OCA], [https://pdbe.org/7oim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oim RCSB], [https://www.ebi.ac.uk/pdbsum/7oim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oim ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/RN213_MOUSE RN213_MOUSE] Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:32573437). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:32573437).[UniProtKB:Q63HN8]<ref>PMID:32573437</ref> <ref>PMID:34012115</ref>

~~Authors: Grabarczyk, D., Ahel, J., Clausen, T.~~

==See Also==

*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]

~~Description: Mouse RNF213, with mixed nucleotides bound~~

== References ==

[[Category: ~~Unreleased~~ Structures]]

[[Category: ~~Clausen, T~~]]

__TOC__

[[Category: Ahel, J]]

</StructureSection>

[[Category: Grabarczyk, D]]

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Ahel J]]

[[Category: Clausen T]]

[[Category: Grabarczyk D]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7oim is ON HOLD
+==Mouse RNF213, with mixed nucleotides bound==
+<StructureSection load='7oim' size='340' side='right'caption='[[7oim]], [[Resolution|resolution]] 4.00&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7oim]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OIM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OIM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=AGS:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>AGS</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oim OCA], [https://pdbe.org/7oim PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oim RCSB], [https://www.ebi.ac.uk/pdbsum/7oim PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oim ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RN213_MOUSE RN213_MOUSE] Atypical E3 ubiquitin ligase that can catalyze ubiquitination of both proteins and lipids, and which is involved in various processes, such as lipid metabolism, angiogenesis and cell-autonomous immunity (PubMed:32573437). Acts as a key immune sensor by catalyzing ubiquitination of the lipid A moiety of bacterial lipopolysaccharide (LPS) via its RZ-type zinc-finger: restricts the proliferation of cytosolic bacteria, such as Salmonella, by generating the bacterial ubiquitin coat through the ubiquitination of LPS (PubMed:34012115). Also acts indirectly by mediating the recruitment of the LUBAC complex, which conjugates linear polyubiquitin chains (By similarity). Ubiquitination of LPS triggers cell-autonomous immunity, such as antibacterial autophagy, leading to degradation of the microbial invader (By similarity). Involved in lipid metabolism by regulating fat storage and lipid droplet formation; act by inhibiting the lipolytic process (By similarity). Also regulates lipotoxicity by inhibiting desaturation of fatty acids (By similarity). Also acts as an E3 ubiquitin-protein ligase via its RING-type zinc finger: mediates 'Lys-63'-linked ubiquitination of target proteins (By similarity). Involved in the non-canonical Wnt signaling pathway in vascular development: acts by mediating ubiquitination and degradation of FLNA and NFATC2 downstream of RSPO3, leading to inhibit the non-canonical Wnt signaling pathway and promoting vessel regression (By similarity). Also has ATPase activity; ATPase activity is required for ubiquitination of LPS (PubMed:32573437).[UniProtKB:Q63HN8]<ref>PMID:32573437</ref> <ref>PMID:34012115</ref>
-Authors: Grabarczyk, D., Ahel, J., Clausen, T.
+==See Also==
+*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
-Description: Mouse RNF213, with mixed nucleotides bound
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Clausen, T]]
+__TOC__
-[[Category: Ahel, J]]
+</StructureSection>
-[[Category: Grabarczyk, D]]
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Ahel J]]
+[[Category: Clausen T]]
+[[Category: Grabarczyk D]]