1ves: Difference between revisions

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[[Image:1ves.png|left|200px]]


{{STRUCTURE_1ves| PDB=1ves | SCENE= }}
==Structure of New Antigen Receptor variable domain from sharks==
<StructureSection load='1ves' size='340' side='right'caption='[[1ves]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1ves]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Orectolobus_maculatus Orectolobus maculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VES FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ves FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ves OCA], [https://pdbe.org/1ves PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ves RCSB], [https://www.ebi.ac.uk/pdbsum/1ves PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ves ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6X1E6_9CHON Q6X1E6_9CHON]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ve/1ves_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ves ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Ig new antigen receptors (IgNARs) are single-domain antibodies found in the serum of sharks. Here, we report 2.2- and 2.8-A structures of the type 2 IgNAR variable domains 12Y-1 and 12Y-2. Structural features include, first, an Ig superfamily topology transitional between cell adhesion molecules, antibodies, and T cell receptors; and, second, a vestigial complementarity-determining region 2 at the "bottom" of the molecule, apparently discontinuous from the antigen-binding paratope and similar to that observed in cell adhesion molecules. Thus, we suggest that IgNARs originated as cell-surface adhesion molecules coopted to the immune repertoire and represent an evolutionary lineage independent of variable heavy chain/variable light chain type antibodies. Additionally, both 12Y-1 and 12Y-2 form unique crystallographic dimers, predominantly mediated by main-chain framework interactions, which represent a possible model for primordial cell-based interactions. Unusually, the 12Y-2 complementarity-determining region 3 also adopts an extended beta-hairpin structure, suggesting a distinct selective advantage in accessing cryptic antigenic epitopes.


===Structure of New Antigen Receptor variable domain from sharks===
Structural evidence for evolution of shark Ig new antigen receptor variable domain antibodies from a cell-surface receptor.,Streltsov VA, Varghese JN, Carmichael JA, Irving RA, Hudson PJ, Nuttall SD Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12444-9. Epub 2004 Aug 10. PMID:15304650<ref>PMID:15304650</ref>


{{ABSTRACT_PUBMED_15304650}}
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
==About this Structure==
<div class="pdbe-citations 1ves" style="background-color:#fffaf0;"></div>
[[1ves]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Orectolobus_maculatus Orectolobus maculatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VES OCA].
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:015304650</ref><references group="xtra"/>
</StructureSection>
[[Category: Large Structures]]
[[Category: Orectolobus maculatus]]
[[Category: Orectolobus maculatus]]
[[Category: Streltsov, V A.]]
[[Category: Streltsov VA]]
[[Category: 12y-2]]
[[Category: Ig vnar]]
[[Category: Immune system]]
Retrieved from "https://proteopedia.org/1ves"