2aeo: Difference between revisions

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{{Seed}}
[[Image:2aeo.png|left|200px]]


<!--
==Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase==
The line below this paragraph, containing "STRUCTURE_2aeo", creates the "Structure Box" on the page.
<StructureSection load='2aeo' size='340' side='right'caption='[[2aeo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2aeo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEO FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_2aeo| PDB=2aeo |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aeo OCA], [https://pdbe.org/2aeo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aeo RCSB], [https://www.ebi.ac.uk/pdbsum/2aeo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aeo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SODC_BOVIN SODC_BOVIN] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aeo_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aeo ConSurf].
<div style="clear:both"></div>


===Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase===
==See Also==
 
*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
2AEO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEO OCA].
 
==Reference==
Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutase., Calderone V, Casini A, Mangani S, Messori L, Orioli PL, Angew Chem Int Ed Engl. 2006 Feb 13;45(8):1267-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16416478 16416478]
 
Structure, Recognition, and Processing of Cisplatin-DNA Adducts., Jamieson ER, Lippard SJ, Chem Rev. 1999 Sep 8;99(9):2467-98. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11749487 11749487]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Superoxide dismutase]]
[[Category: Calderone V]]
[[Category: Calderone, V.]]
[[Category: Casini A]]
[[Category: Casini, A.]]
[[Category: Mangani S]]
[[Category: Mangani, S.]]
[[Category: Messori L]]
[[Category: Messori, L.]]
[[Category: Orioli PL]]
[[Category: Orioli, P L.]]
[[Category: Cancer]]
[[Category: Cisplatin]]
[[Category: Cu,zn sod]]
[[Category: Metal based drug]]
[[Category: Platinum]]
[[Category: Protein]]
[[Category: Sod]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:11:05 2008''

Latest revision as of 07:48, 30 October 2024

Crystal structure of cisplatinated bovine Cu,Zn superoxide dismutase

2aeo, resolution 1.80Å

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