2g8y: Difference between revisions

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New page: left|200px<br /><applet load="2g8y" size="450" color="white" frame="true" align="right" spinBox="true" caption="2g8y, resolution 2.15Å" /> '''The structure of a p...
 
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[[Image:2g8y.gif|left|200px]]<br /><applet load="2g8y" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2g8y, resolution 2.15&Aring;" />
'''The structure of a putative malate/lactate dehydrogenase from E. coli.'''<br />


==About this Structure==
==The structure of a putative malate/lactate dehydrogenase from E. coli.==
2G8Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SO4, NAD, EDO and 1PE as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2G8Y OCA].  
<StructureSection load='2g8y' size='340' side='right'caption='[[2g8y]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
[[Category: Escherichia coli]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2g8y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G8Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G8Y FirstGlance]. <br>
[[Category: Cuff, M.E.]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
[[Category: Cymborowski, M.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Edwards, A.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g8y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g8y OCA], [https://pdbe.org/2g8y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g8y RCSB], [https://www.ebi.ac.uk/pdbsum/2g8y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g8y ProSAT], [https://www.topsan.org/Proteins/MCSG/2g8y TOPSAN]</span></td></tr>
[[Category: Joachimiak, A.]]
</table>
[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
== Function ==
[[Category: Minor, W.]]
[https://www.uniprot.org/uniprot/HCXB_ECOLI HCXB_ECOLI] Catalyzes the NAD(P)H-dependent reduction of 2-oxoglutarate, phenylpyruvate and (4-hydroxyphenyl)pyruvate, leading to the respective 2-hydroxycarboxylate in vitro. Shows a preference for NADPH over NADH as a redox partner. Do not catalyze the reverse reactions.<ref>PMID:27941785</ref>
[[Category: Savchenko, A.]]
== Evolutionary Conservation ==
[[Category: Skarina, T.]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: 1PE]]
Check<jmol>
[[Category: EDO]]
  <jmolCheckbox>
[[Category: NAD]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g8/2g8y_consurf.spt"</scriptWhenChecked>
[[Category: SO4]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
[[Category: dehydrogenase]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: e.coli]]
  </jmolCheckbox>
[[Category: lactate]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g8y ConSurf].
[[Category: malate]]
<div style="clear:both"></div>
[[Category: mcsg]]
[[Category: midwest center for structural genomics]]
[[Category: nad]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomics]]


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 11:02:41 2007''
==See Also==
*[[Lactate dehydrogenase 3D structures|Lactate dehydrogenase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Cuff ME]]
[[Category: Cymborowski M]]
[[Category: Edwards A]]
[[Category: Joachimiak A]]
[[Category: Minor W]]
[[Category: Savchenko A]]
[[Category: Skarina T]]
Retrieved from "https://proteopedia.org/2g8y"