2mj0: Difference between revisions

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~~'''Unreleased structure'''~~

~~The entry~~ 2mj0 is ~~ON HOLD~~

==Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia==

~~Authors~~: ~~Paramonov~~, A.S., ~~Shenkarev~~, Z.O., ~~Lyukmanova~~, E.N.

== Structural highlights ==

<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>

~~Description~~: ~~Spatial structure~~ of ~~P33A mutant~~ of ~~non~~-~~conventional toxin WTX from~~ Naja kaouthia

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [https://pdbe.org/2mj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj0 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/3NO2_NAJKA 3NO2_NAJKA] Neurotoxin that irreversibly inhibits nicotinic acetylcholine receptors (nAChR) and allosterically interacts with muscarinic acetylcholine receptors (mAChR) (PubMed:11279130, PubMed:19682302). The loop II is involved in the interaction of this toxin with nAChR and mAChR (PubMed:26242733, PubMed:27343701). On nAChR, it acts as a competitive antagonist (muscle-type and alpha-7/CHRNA7) with IC(50) values in the micromolar range (PubMed:11279130, PubMed:27343701). On mAChR, in presence of ACh, it partially inhibits the effect of acetylcholine (ACh) (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist) (PubMed:19682302). It also shows a very weak inhibition of GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1 and GABRB3 and GABRG2) subunits (10 uM inhibit 31% current) (PubMed:26221036). In vivo, is nonlethal to mice at concentrations up to 20 mg/kg, but exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats (PubMed:15581687, PubMed:17371532).<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref> <ref>PMID:26221036</ref> <ref>PMID:27343701</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Naja kaouthia]]

[[Category: Lyukmanova EN]]

[[Category: Paramonov AS]]

[[Category: Shenkarev ZO]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 2mj0 is ON HOLD
+==Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia==
+<StructureSection load='2mj0' size='340' side='right'caption='[[2mj0]]' scene=''>
-Authors: Paramonov, A.S., Shenkarev, Z.O., Lyukmanova, E.N.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2mj0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_kaouthia Naja kaouthia]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJ0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJ0 FirstGlance]. <br>
-Description: Spatial structure of P33A mutant of non-conventional toxin WTX from Naja kaouthia
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mj0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mj0 OCA], [https://pdbe.org/2mj0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mj0 RCSB], [https://www.ebi.ac.uk/pdbsum/2mj0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mj0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/3NO2_NAJKA 3NO2_NAJKA] Neurotoxin that irreversibly inhibits nicotinic acetylcholine receptors (nAChR) and allosterically interacts with muscarinic acetylcholine receptors (mAChR) (PubMed:11279130, PubMed:19682302). The loop II is involved in the interaction of this toxin with nAChR and mAChR (PubMed:26242733, PubMed:27343701). On nAChR, it acts as a competitive antagonist (muscle-type and alpha-7/CHRNA7) with IC(50) values in the micromolar range (PubMed:11279130, PubMed:27343701). On mAChR, in presence of ACh, it partially inhibits the effect of acetylcholine (ACh) (allosteric antagonist), whereas in the absence of ACh, it activates the receptor (allosteric agonist) (PubMed:19682302). It also shows a very weak inhibition of GABA(A) receptor composed of alpha-1-beta-3-gamma-2 (GABRA1 and GABRB3 and GABRG2) subunits (10 uM inhibit 31% current) (PubMed:26221036). In vivo, is nonlethal to mice at concentrations up to 20 mg/kg, but exerts a myorelaxant effect, induces a dose-dependent decrease in blood pressure and an increase in heart rate in mice and rats (PubMed:15581687, PubMed:17371532).<ref>PMID:11279130</ref> <ref>PMID:15581687</ref> <ref>PMID:17371532</ref> <ref>PMID:19682302</ref> <ref>PMID:26221036</ref> <ref>PMID:27343701</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Naja kaouthia]]
+[[Category: Lyukmanova EN]]
+[[Category: Paramonov AS]]
+[[Category: Shenkarev ZO]]