2odt: Difference between revisions

==Structure of human Inositol 1,3,4-trisphosphate 5/6-kinase==

<StructureSection load='2odt' size='340' side='right'caption='[[2odt]], [[Resolution|resolution]] 2.01&Aring;' scene=''>

== Structural highlights ==

<table><tr><td colspan='2'>[[2odt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odt OCA], [https://pdbe.org/2odt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odt RCSB], [https://www.ebi.ac.uk/pdbsum/2odt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odt ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ITPK1_HUMAN ITPK1_HUMAN] Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain.<ref>PMID:11533064</ref> <ref>PMID:11909533</ref> <ref>PMID:12925536</ref> <ref>PMID:17616525</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

    <text>to colour the structure by Evolutionary Conservation</text>

</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2odt ConSurf].

[[Category: Large Structures]]

[[Category: Arrowsmith C]]

[[Category: Berglund H]]

[[Category: Busam RD]]

[[Category: Collins R]]

[[Category: Edwards A]]

[[Category: Ericsson UB]]

[[Category: Flodin S]]

[[Category: Flores A]]

[[Category: Hallberg BM]]

[[Category: Hammarstrom M]]

[[Category: Holmberg SL]]

[[Category: Johansson I]]

[[Category: Karlberg T]]

[[Category: Kotenyova T]]

[[Category: Moche M]]

[[Category: Nilsson ME]]

[[Category: Nordlund P]]

[[Category: Nyman T]]

[[Category: Ogg D]]

[[Category: Persson C]]

[[Category: Sagemark J]]

[[Category: Sundstrom M]]

[[Category: Thorsell AG]]

[[Category: Uppenberg J]]

[[Category: Van Den Berg S]]

[[Category: Weigelt J]]