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==Crystal structure of Staphylococcal Complement Inhibitor==
==Crystal structure of Staphylococcal Complement Inhibitor==
<StructureSection load='2qff' size='340' side='right' caption='[[2qff]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='2qff' size='340' side='right'caption='[[2qff]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qff]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staar Staar]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QFF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qff]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_MRSA252 Staphylococcus aureus subsp. aureus MRSA252]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QFF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QFF FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">YP_041408/SAR2035 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=282458 STAAR])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qff OCA], [http://pdbe.org/2qff PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qff RCSB], [http://www.ebi.ac.uk/pdbsum/2qff PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2qff ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qff FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qff OCA], [https://pdbe.org/2qff PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qff RCSB], [https://www.ebi.ac.uk/pdbsum/2qff PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qff ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SCIN_STAA3 SCIN_STAA3]] Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (By similarity).  
[https://www.uniprot.org/uniprot/SCIN_STAAR SCIN_STAAR] Involved in countering the first line of host defense mechanisms. Efficiently inhibits opsonization, phagocytosis and killing of S.aureus by human neutrophils. Acts by binding and stabilizing human C3 convertases (C4b2a and C3bBb), leading to their inactivation. The convertases are no longer able to cleave complement C3, therefore preventing further C3b deposition on the bacterial surface and phagocytosis of the bacterium. Also prevents C5a-induced neutrophil responses (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Staar]]
[[Category: Large Structures]]
[[Category: Bardoel, B W]]
[[Category: Staphylococcus aureus subsp. aureus MRSA252]]
[[Category: Gros, P]]
[[Category: Bardoel BW]]
[[Category: Milder, F J]]
[[Category: Gros P]]
[[Category: Rooijakkers, S H.M]]
[[Category: Milder FJ]]
[[Category: Ruyken, M]]
[[Category: Rooijakkers SHM]]
[[Category: Strijp, J A.G Van]]
[[Category: Ruyken M]]
[[Category: Bacterial]]
[[Category: Van Strijp JAG]]
[[Category: Complement]]
[[Category: Hydrolase inhibitor]]
[[Category: Inflammation]]
[[Category: Inhibitor]]
[[Category: Molecular biology]]
Retrieved from "https://proteopedia.org/2qff"