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{{STRUCTURE_3lm8|  PDB=3lm8  |  SCENE=  }}
===Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677===


==Function==
==Crystal Structure of Thiamine pyrophosphokinase from Bacillus subtilis, Northeast Structural Genomics Consortium Target SR677==
[[http://www.uniprot.org/uniprot/THIN_BACSU THIN_BACSU]] Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate.  
<StructureSection load='3lm8' size='340' side='right'caption='[[3lm8]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3lm8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LM8 FirstGlance]. <br>
[[3lm8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LM8 OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lm8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lm8 OCA], [https://pdbe.org/3lm8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lm8 RCSB], [https://www.ebi.ac.uk/pdbsum/3lm8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lm8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/THIN_BACSU THIN_BACSU] Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lm/3lm8_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lm8 ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Thiamine diphosphokinase]]
[[Category: Large Structures]]
[[Category: Abashidze, M.]]
[[Category: Abashidze M]]
[[Category: Acton, T B.]]
[[Category: Acton TB]]
[[Category: Ciccosanti, C.]]
[[Category: Ciccosanti C]]
[[Category: Everett, J K.]]
[[Category: Everett JK]]
[[Category: Foote, E L.]]
[[Category: Foote EL]]
[[Category: Hunt, J F.]]
[[Category: Hunt JF]]
[[Category: Kuzin, A.]]
[[Category: Kuzin A]]
[[Category: Mao, M.]]
[[Category: Mao M]]
[[Category: Montelione, G T.]]
[[Category: Montelione GT]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Nair R]]
[[Category: Nair, R.]]
[[Category: Rost B]]
[[Category: Rost, B.]]
[[Category: Seetharaman J]]
[[Category: Seetharaman, J.]]
[[Category: Tong L]]
[[Category: Tong, L.]]
[[Category: Wang H]]
[[Category: Wang, H.]]
[[Category: Xiao R]]
[[Category: Xiao, R.]]
[[Category: Atp-binding]]
[[Category: Kinase]]
[[Category: Nesg]]
[[Category: Northeast structural genomics consortium]]
[[Category: Nucleotide-binding]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Structural genomic]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/3lm8"