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{{STRUCTURE_3re3|  PDB=3re3  |  SCENE=  }}
===Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase from Francisella tularensis===


==Function==
==Crystal Structure of 2-C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase from Francisella tularensis==
[[http://www.uniprot.org/uniprot/ISPF_FRATT ISPF_FRATT]] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]  
<StructureSection load='3re3' size='340' side='right'caption='[[3re3]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[3re3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis_SCHU_S4 Francisella tularensis subsp. tularensis SCHU S4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RE3 FirstGlance]. <br>
[[3re3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Francisella_tularensis_subsp._tularensis Francisella tularensis subsp. tularensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RE3 OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.645&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3re3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3re3 OCA], [https://pdbe.org/3re3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3re3 RCSB], [https://www.ebi.ac.uk/pdbsum/3re3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3re3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ISPF_FRATT ISPF_FRATT] Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity).[HAMAP-Rule:MF_00107]


==See Also==
==See Also==
*[[MECDP synthase|MECDP synthase]]
*[[MECDP synthase 3D structures|MECDP synthase 3D structures]]
[[Category: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase]]
__TOC__
[[Category: Francisella tularensis subsp. tularensis]]
</StructureSection>
[[Category: Anderson, W F.]]
[[Category: Francisella tularensis subsp. tularensis SCHU S4]]
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
[[Category: Large Structures]]
[[Category: Joachimiak, A.]]
[[Category: Anderson WF]]
[[Category: Kim, Y.]]
[[Category: Joachimiak A]]
[[Category: Kwon, K.]]
[[Category: Kim Y]]
[[Category: Makowska-Grzyska, M.]]
[[Category: Kwon K]]
[[Category: Alpha-beta half sandwich]]
[[Category: Makowska-Grzyska M]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Csgid]]
[[Category: Cytosol]]
[[Category: Lyase]]
[[Category: Structural genomic]]
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