4rhg: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhg OCA], [https://pdbe.org/4rhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhg RCSB], [https://www.ebi.ac.uk/pdbsum/4rhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhg ProSAT]</span></td></tr>

</table>

~~== Disease ==~~

[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.

== Function ==

[https://www.uniprot.org/uniprot/~~EPS15_HUMAN EPS15_HUMAN~~] ~~Involved in cell growth regulation.~~ May ~~be involved in~~ the ~~regulation of mitogenic signals~~ and ~~control of cell proliferation~~. ~~Involved in the internalization of ligand-inducible receptors of the receptor~~ tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.~~<ref>PMID:18362181</ref> <ref>PMID:19458185</ref> <ref>PMID:22648170</ref> <ref>PMID:16903783</ref>~~

[https://www.uniprot.org/uniprot/PTN3_HUMAN PTN3_HUMAN] May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

== Publication Abstract from PubMed ==

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@@ Line 8: / Line 8: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rhg OCA], [https://pdbe.org/4rhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rhg RCSB], [https://www.ebi.ac.uk/pdbsum/4rhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rhg ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with MLL/HRX. The result is a rogue activator protein.
 == Function ==
-[https://www.uniprot.org/uniprot/EPS15_HUMAN EPS15_HUMAN] Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.<ref>PMID:18362181</ref> <ref>PMID:19458185</ref> <ref>PMID:22648170</ref> <ref>PMID:16903783</ref>
+[https://www.uniprot.org/uniprot/PTN3_HUMAN PTN3_HUMAN] May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==