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[[Image:2cfy.gif|left|200px]]


{{Structure
==Crystal structure of human thioredoxin reductase 1==
|PDB= 2cfy |SIZE=350|CAPTION= <scene name='initialview01'>2cfy</scene>, resolution 2.70&Aring;
<StructureSection load='2cfy' size='340' side='right'caption='[[2cfy]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
|SITE= <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+F'>AC1</scene>
== Structural highlights ==
|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
<table><tr><td colspan='2'>[[2cfy]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CFY FirstGlance]. <br>
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thioredoxin-disulfide_reductase Thioredoxin-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.9 1.8.1.9] </span>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
|GENE=  
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr>
|DOMAIN=
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfy OCA], [https://pdbe.org/2cfy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cfy RCSB], [https://www.ebi.ac.uk/pdbsum/2cfy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cfy ProSAT]</span></td></tr>
|RELATEDENTRY=
</table>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cfy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cfy OCA], [http://www.ebi.ac.uk/pdbsum/2cfy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cfy RCSB]</span>
== Function ==
}}
[https://www.uniprot.org/uniprot/TRXR1_HUMAN TRXR1_HUMAN] Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid.<ref>PMID:9774665</ref> <ref>PMID:8577704</ref> <ref>PMID:15199063</ref> <ref>PMID:18042542</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cf/2cfy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cfy ConSurf].
<div style="clear:both"></div>


'''CRYSTAL STRUCTURE OF HUMAN THIOREDOXIN REDUCTASE 1'''
==See Also==
 
*[[Thioredoxin reductase 3D structures|Thioredoxin reductase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2CFY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CFY OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Thioredoxin-disulfide reductase]]
[[Category: Arrowsmith C]]
[[Category: Arrowsmith, C.]]
[[Category: Debreczeni JE]]
[[Category: Debreczeni, J E.]]
[[Category: Edwards A]]
[[Category: Delft, F Von.]]
[[Category: Johansson C]]
[[Category: Edwards, A.]]
[[Category: Kavanagh K]]
[[Category: Johansson, C.]]
[[Category: Oppermann U]]
[[Category: Kavanagh, K.]]
[[Category: Savitsky P]]
[[Category: Oppermann, U.]]
[[Category: Sundstrom M]]
[[Category: Savitsky, P.]]
[[Category: Weigelt J]]
[[Category: Sundstrom, M.]]
[[Category: Von Delft F]]
[[Category: Weigelt, J.]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: phosphorylation]]
[[Category: redox-active center]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:20:58 2008''
Retrieved from "https://proteopedia.org/2cfy"