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{{STRUCTURE_2miq|  PDB=2miq  |  SCENE=  }}
===Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J===


==Function==
==Solution NMR Structure of PHD Type 1 Zinc Finger Domain 1 of Lysine-specific Demethylase Lid from Drosophila melanogaster, Northeast Structural Genomics Consortium (NESG) Target FR824J==
[[http://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME]] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref>
<StructureSection load='2miq' size='340' side='right'caption='[[2miq]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[2miq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MIQ FirstGlance]. <br>
[[2miq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MIQ OCA].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2miq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2miq OCA], [https://pdbe.org/2miq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2miq RCSB], [https://www.ebi.ac.uk/pdbsum/2miq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2miq ProSAT]</span></td></tr>
<references group="xtra"/><references/>
</table>
[[Category: CEBS, Chaperone-Enabled Studies of Epigenetic Regulation Enzymes.]]
== Function ==
[[Category: Elestky, A.]]
[https://www.uniprot.org/uniprot/KDM5_DROME KDM5_DROME] Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Specifically demethylates trimethylated H3 'Lys-4'. Required for the correct regulation of homeotic genes during development.<ref>PMID:11014813</ref> <ref>PMID:17311883</ref> <ref>PMID:17351631</ref> <ref>PMID:17351630</ref>  
[[Category: Everett, J K.]]
== References ==
[[Category: Janjua, H.]]
<references/>
[[Category: Maglaqui, M.]]
__TOC__
[[Category: Montelione, G T.]]
</StructureSection>
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Drosophila melanogaster]]
[[Category: Shastry, R.]]
[[Category: Large Structures]]
[[Category: Sukumaran, D K.]]
[[Category: Eletsky A]]
[[Category: Szyperski, T.]]
[[Category: Everett JK]]
[[Category: Xiao, R.]]
[[Category: Janjua H]]
[[Category: Xu, X.]]
[[Category: Maglaqui M]]
[[Category: Oxidoreductase]]
[[Category: Montelione GT]]
[[Category: Psi-biology]]
[[Category: Shastry R]]
[[Category: Zinc finger]]
[[Category: Sukumaran DK]]
[[Category: Szyperski T]]
[[Category: Xiao R]]
[[Category: Xu X]]
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