3lof: Difference between revisions

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{{Seed}}
[[Image:3lof.jpg|left|200px]]


<!--
==C-terminal domain of human heat shock 70kDa protein 1B.==
The line below this paragraph, containing "STRUCTURE_3lof", creates the "Structure Box" on the page.
<StructureSection load='3lof' size='340' side='right'caption='[[3lof]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3lof]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LOF FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3lof| PDB=3lof |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lof OCA], [https://pdbe.org/3lof PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lof RCSB], [https://www.ebi.ac.uk/pdbsum/3lof PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lof ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS71A_HUMAN HS71A_HUMAN] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223).<ref>PMID:16537599</ref> <ref>PMID:22528486</ref> <ref>PMID:23973223</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lo/3lof_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lof ConSurf].
<div style="clear:both"></div>


===C-terminal domain of human heat shock 70kDa protein 1B.===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
==About this Structure==
<references/>
3LOF is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LOF OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Gu, M.]]
[[Category: Large Structures]]
[[Category: Joachimiak, A.]]
[[Category: Gu M]]
[[Category: MCSG, Midwest Center for Structural Genomics.]]
[[Category: Joachimiak A]]
[[Category: Mihelic, M.]]
[[Category: Mihelic M]]
[[Category: Morimoto, R I.]]
[[Category: Morimoto RI]]
[[Category: Orton, K.]]
[[Category: Orton K]]
[[Category: Osipiuk, J.]]
[[Category: Osipiuk J]]
[[Category: Acetylation]]
[[Category: Atp-binding]]
[[Category: Chaperone]]
[[Category: Cytoplasm]]
[[Category: Heat shock]]
[[Category: Hsp70]]
[[Category: Hspa1b]]
[[Category: Mcsg]]
[[Category: Midwest center for structural genomic]]
[[Category: Nucleotide-binding]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Protein structure initiative]]
[[Category: Psi-2]]
[[Category: Stress response]]
[[Category: Structural genomic]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 17 10:56:51 2010''
Retrieved from "https://proteopedia.org/3lof"