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==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4S)==
==Crystal structures of the murine class I major histocompatibility complex H-2Db in complex with LCMV-derived gp33 altered peptide ligand (Y4S)==
<StructureSection load='3qul' size='340' side='right' caption='[[3qul]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3qul' size='340' side='right'caption='[[3qul]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qul]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QUL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qul]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis_virus_(strain_WE) Lymphocytic choriomeningitis virus (strain WE)] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QUL FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1s7u|1s7u]], [[1s7v|1s7v]], [[1s7w|1s7w]], [[1s7x|1s7x]], [[3quk|3quk]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qul OCA], [http://pdbe.org/3qul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qul RCSB], [http://www.ebi.ac.uk/pdbsum/3qul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qul ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qul OCA], [https://pdbe.org/3qul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qul RCSB], [https://www.ebi.ac.uk/pdbsum/3qul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qul ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/GLYC_LYCVW GLYC_LYCVW]] The stable signal peptide (SSP) is cleaved and functions as a signal peptide. In addition, it is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity).  Glycoprotein G1 mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis (By similarity).  Glycoprotein G2 is a viral fusion protein. Membrane fusion is mediated by conformational changes induced upon acidification in the endosome (Potential). [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.  
[https://www.uniprot.org/uniprot/HA11_MOUSE HA11_MOUSE] Involved in the presentation of foreign antigens to the immune system.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Beta-2 microglobulin|Beta-2 microglobulin]]
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
*[[Major histocompatibility complex|Major histocompatibility complex]]
*[[MHC 3D structures|MHC 3D structures]]
*[[MHC I 3D structures|MHC I 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Achour, A]]
[[Category: Large Structures]]
[[Category: Allerbring, E]]
[[Category: Mus musculus]]
[[Category: Duru, A D]]
[[Category: Achour A]]
[[Category: Friemann, R]]
[[Category: Allerbring E]]
[[Category: Grimm, S]]
[[Category: Duru AD]]
[[Category: Madhurantakam, C]]
[[Category: Friemann R]]
[[Category: Mazumdar, P A]]
[[Category: Grimm S]]
[[Category: Nygren, P]]
[[Category: Madhurantakam C]]
[[Category: Sandalova, T]]
[[Category: Mazumdar PA]]
[[Category: Spetz, A]]
[[Category: Nygren P]]
[[Category: Tomek, M B]]
[[Category: Sandalova T]]
[[Category: Uchtenhagen, H]]
[[Category: Spetz A]]
[[Category: Uhlin, M]]
[[Category: Tomek MB]]
[[Category: Beta2-microglobulin]]
[[Category: Uchtenhagen H]]
[[Category: Cell surface]]
[[Category: Uhlin M]]
[[Category: Immune system]]
[[Category: Lcmv]]
[[Category: Murine mhc]]
[[Category: Receptor binding]]
[[Category: T cell receptor]]
[[Category: T cell recognition]]
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